Dynamic Hyperinflation During Maximal Voluntary Ventilation in Healthy Subjects

NCT ID: NCT02831465

Last Updated: 2017-02-02

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 45 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-04-30
• Study Completion Date: 2017-06-30

Brief Summary

Maximal Voluntary Ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation.

The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.

Detailed Description

Maximal voluntary ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation. The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.

Study design: healthy subjects with normal lung function will perform MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) will be measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeares at a given frequency, only one additional MVV at a higher breathing frequency will be conducted to confirm DH.

Conditions

Dynamic Hyperinflation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

healthy subjects

Subjects with normal lung function between 40 and 70 years old.

Group Type: EXPERIMENTAL

Healthy Subjects

Intervention Type: BEHAVIORAL

Subjects with normal lung function performed MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) was measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeared at a given frequency, only one additional MVV at a higher breathing frequency was conducted to confirm DH.

Interventions

Healthy Subjects

Subjects with normal lung function performed MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) was measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeared at a given frequency, only one additional MVV at a higher breathing frequency was conducted to confirm DH.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy subjects

Exclusion Criteria

• History of asthma, obstructive syndrome on basic lung function

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 69 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire Saint Pierre

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Vincent Ninane, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Center Saint Pierre chest service

Locations

CHU St. Pierre

Brussels, Brussels Capital, Belgium

Site Status: RECRUITING

Countries

Belgium

Central Contacts

Audrey Herpeux

Role: CONTACT

audrey_herpeux@stpierre-bru.be

003225067323

Inge Muylle, MD

Role: CONTACT

inge_muylle@stpierre-bru.be

003225354295

Facility Contacts

Audrey Herpeux

Role: primary

audrey_herpeux@stpierre-bru.be

+3225067323

Other Identifiers

B076201318918

Identifier Type: -

Identifier Source: org_study_id