Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
NCT ID: NCT02791139
Last Updated: 2016-06-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
800 participants
OBSERVATIONAL
2014-07-31
2017-04-30
Brief Summary
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Detailed Description
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These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Control
Healthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis
Cardiovascular Magnetic Resonance Imaging (MRI)
Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.
Echocardiography
To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
Tonometry
Tonometry is a noninvasive method to obtain arterial pressure waveform
Genetic Testing (Blood)
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
Hand-Grip Strength Measurement
We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.
Body Fat Mass Analysis
Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.
Ageing
Ageing cohort will undergo the following studying procedures:
Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis
Cardiovascular Magnetic Resonance Imaging (MRI)
Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.
Echocardiography
To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
Tonometry
Tonometry is a noninvasive method to obtain arterial pressure waveform
Genetic Testing (Blood)
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
Body Fat Mass Analysis
Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.
Interventions
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Cardiovascular Magnetic Resonance Imaging (MRI)
Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.
Echocardiography
To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
Tonometry
Tonometry is a noninvasive method to obtain arterial pressure waveform
Genetic Testing (Blood)
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
Hand-Grip Strength Measurement
We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.
Body Fat Mass Analysis
Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.
Eligibility Criteria
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Inclusion Criteria
* Had been interviewed at baseline and at the two follow-up interviews
* Had provided biospecimens for research previously before the age of 65 years (2000-2004)
* Who will be 65 years or older by 2013
Exclusion Criteria
* Anticipated life expectancy \< 1 year
* Unable to provide written informed consent to participate in the study
* Patients with cancer
* Patients with chronic renal disease
* Any metallic implants
60 Years
ALL
Yes
Sponsors
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National University of Singapore
OTHER
National Heart Centre Singapore
OTHER
Responsible Party
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Principal Investigators
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Su-Mei Angela Koh, MBBS
Role: PRINCIPAL_INVESTIGATOR
National Heart Centre Singapore
Locations
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National Heart Centre Singapore
Singapore, Singapore, Singapore
Countries
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Central Contacts
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Facility Contacts
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References
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Wong JJ, Zhang H, Leng S, Gao F, Zhao X, Tan K, Tan RS, Zhong L, Koh AS. Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk. Eur Heart J Imaging Methods Pract. 2025 Jun 4;3(1):qyaf075. doi: 10.1093/ehjimp/qyaf075. eCollection 2025 Jan.
Wang LYT, Lim WS, Tan RS, Teo LLY, Tan SY, Ooi CH, Ong ACW, Kovalik JP, Goh J, Gao F, Koh AS. Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging. Sci Rep. 2025 May 5;15(1):15679. doi: 10.1038/s41598-025-00657-4.
Chng ACC, Tan HC, Teo LLY, Tan RS, Ewe SH, Leng S, Zhao XD, Zhong L, Koh WP, Kovalik JP, Gao F, Koh AS. Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging. Geroscience. 2025 Apr;47(2):1911-1921. doi: 10.1007/s11357-024-01387-7. Epub 2024 Oct 14.
Zhang H, Leng S, Gao F, Kovalik JP, Tan RS, Wee HN, Chua KV, Ching J, Zhao X, Allen J, Wu Q, Leiner T, Zhong L, Koh AS. Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging. Geroscience. 2024 Dec;46(6):5459-5471. doi: 10.1007/s11357-024-01127-x. Epub 2024 Mar 22.
Tan YH, Lim JP, Lim WS, Gao F, Teo LLY, Ewe SH, Keng BMH, Tan RS, Koh WP, Koh AS. Obesity in Older Adults and Associations with Cardiovascular Structure and Function. Obes Facts. 2022;15(3):336-343. doi: 10.1159/000521729. Epub 2022 Mar 4.
Kovalik JP, Zhao X, Gao F, Leng S, Chow V, Chew H, Teo LLY, Tan RS, Ewe SH, Tan HC, Wee HN, Lee LS, Ching J, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function. J Mol Cell Cardiol. 2021 Sep;158:63-71. doi: 10.1016/j.yjmcc.2021.05.009. Epub 2021 May 24.
Koh AS, Velmurugan B, Gao F, Tan RS, Wong JI, Teo LLY, Keng BMH, Chua SJM, Yuan JM, Koh WP, Cheung C. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. doi: 10.1186/s12877-017-0668-0.
Other Identifiers
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2014/628/C
Identifier Type: -
Identifier Source: org_study_id
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