Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance

NCT ID: NCT02779972

Last Updated: 2018-02-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 250 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-03-01
• Study Completion Date: 2018-02-04

Brief Summary

Aging is associated with numerous changes and adaptations in the cardiovascular system. Vascular and ventricular wall thickness increase, whereas arterial compliance, endothelial function, and ventricular contractility decline. The decline in cardiac function with advancing age is typically seen in parallel to reduced physical activity, and it has been proposed that lifelong exercise training might attenuate the effects of aging on the heart.

The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle.

Detailed Description

Previous large studies have concluded that resting LV diastolic and systolic function decline with age. The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle. Studies of aging and physical activity usually compare older athletes with sedentary ones, in which physical activity was not found to attenuate the impact on the aging heart. Thus, the investigators set of to find the difference between hearts of elderly who are physically fit as measured with METS to those who are not. And try and understand the basis of this difference.

Conditions

Aging; Exercise Tolerance

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

60's decade

60's decade Echo stress test

Echo stress test

Intervention Type: OTHER

Echo stress test

70's decade

70's decade Echo stress test

Echo stress test

Intervention Type: OTHER

Echo stress test

80's decade

80's decade Echo stress test

Echo stress test

Intervention Type: OTHER

Echo stress test

Interventions

Echo stress test

Echo stress test

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in the facility.

Exclusion Criteria

• Missing complete information used for data collection.

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tel-Aviv Sourasky Medical Center

OTHER_GOV

Sponsor Role: lead

Responsible Party

michal roll

Director. Research & Development

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ehud Chorin, MD

Role: PRINCIPAL_INVESTIGATOR

972-3-6947520

Locations

The Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Countries

Israel

Other Identifiers

TASMC-16-UC-0090-16-TLV-CTIL

Identifier Type: -

Identifier Source: org_study_id