Effect of His-Ventricular (HV) Interval Optimisation in Cardiac Resynchronisation Therapy
NCT ID: NCT02748876
Last Updated: 2019-07-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2016-09-29
2018-03-15
Brief Summary
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The investigators propose a new method to achieve atrioventricular synchrony in CRT based on measurements of electrical conduction from within the heart. Patients referred for CRT implantation at Castle Hill Hospital are eligible to participate. During CRT implantation, additional measurements, will be recorded from within the heart. After implantation, device settings will be adjusted to either standard or electrophysiologically-optimised settings with cross-over at 4 months.
The investigators hypothesis is that patients with optimised settings will derive additional benefit compared to patients with standard pacemaker-determined settings.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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His-Ventricular (HV)-optimised
His-Ventricular (HV) optimised atrioventricular delay
His-Ventricular (HV) optimisation
Optimisation of atrioventricular pacing interval
Non-optimised
Standard atrioventricular delay
No interventions assigned to this group
Interventions
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His-Ventricular (HV) optimisation
Optimisation of atrioventricular pacing interval
Eligibility Criteria
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Inclusion Criteria
* Referred for cardiac resynchronisation therapy (CRT) with or without defibrillator
* In sinus rhythm
* Patients must have a telephone
* Ability to give informed consent
* Ability to complete the study
Exclusion Criteria
* Previous atrial flutter ablation
* Chronic kidney disease Stage 3 or above
* Recent myocardial infarction
* Ongoing cardiac ischaemia
* Infiltrative cardiomyopathy
* Wolff-Parkinson White syndrome
* Presence of second or third degree heart block
* \<90% biventricular pacing at 3 months
* Hypertrophic cardiomyopathy
* Pregnancy or breastfeeding
* On treatment for hypothyroidism or hyperthyroidism
18 Years
ALL
No
Sponsors
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Hull University Teaching Hospitals NHS Trust
OTHER_GOV
Responsible Party
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Locations
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Castle Hill Hospital
Hull, , United Kingdom
Countries
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Other Identifiers
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113
Identifier Type: -
Identifier Source: org_study_id
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