A Study Comparing LBAL to Humira® in Subjects With Active Rheumatoid Arthritis Despite Methotrexate Therapy

NCT ID: NCT02746380

Last Updated: 2021-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

383 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-04-13

Study Completion Date

2018-02-23

Brief Summary

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This is a randomized, double-blind, parallel group, multicenter clinical study to evaluate the efficacy, safety, pharmacokinetics and immunogenicity of LBAL compared to Humira® in subjects with active Rheumatoid Arthritis despite Methotrexate therapy.

Detailed Description

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Conditions

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Arthritis, Rheumatoid

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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LBAL

Adalimumab

Group Type EXPERIMENTAL

LBAL

Intervention Type DRUG

Adalimumab

Humira®

Adalimumab

Group Type ACTIVE_COMPARATOR

Humira®

Intervention Type DRUG

Adalimumab

Interventions

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LBAL

Adalimumab

Intervention Type DRUG

Humira®

Adalimumab

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or Female patients from 20 years to 75 years of age when signing Informed Consent.
* Diagnosed as having RA (Rheumatoid Arthritis) according to the revised 1987 ACR (American College of Rheumatology) criteria for at least 3 months prior to screening
* Patients who have inadequate response to MTX administered for at least 12 weeks before the beginning of screening period and on a stable dose.

Exclusion Criteria

* patients with active tuberculosis or latent tuberculosis based on current clinical symptoms, chest X-ray test and IFN-γ release assay at screening
* patients with any of the following concomitant diseases and/or history within 24 weeks before the first administration of investigational products in this study; Serious infectious disease, Opportunistic infection, Chronic or recurrent infectious disease
* patients with any seropositive result for hepatitis B or hepatitis C or HIV
* patients who have any of the following diseases; Sepsis, Demyelinating disorders, Lymphoproliferative disease, Infection with prosthetic joint, Autoimmune diseases other than rheumatoid arthritis
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mochida Pharmaceutical Company, Ltd.

INDUSTRY

Sponsor Role collaborator

LG Life Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Mochida Investigational site

Tokyo, , Japan

Site Status

LGLS Investigational site

Seoul, , South Korea

Site Status

Countries

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Japan South Korea

Other Identifiers

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LG-ALCL002

Identifier Type: -

Identifier Source: org_study_id

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