Pharmacokinetics and Safety Study of LBAL in Healthy Subjects

NCT ID: NCT02206867

Last Updated: 2015-06-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

116 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-08-31

Study Completion Date

2015-02-28

Brief Summary

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To compare PK, safety and tolerability of LBAL developed by LG Life Sciences Ltd. With those of Humira®.

Detailed Description

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Conditions

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Healthy Subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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LBAL

Developed by LG Life Sciences

Group Type EXPERIMENTAL

LBAL

Intervention Type BIOLOGICAL

Anti-inflammatory agents

Humira®

Abbvie

Group Type ACTIVE_COMPARATOR

Humira

Intervention Type BIOLOGICAL

Anti-inflammatory agents

Interventions

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LBAL

Anti-inflammatory agents

Intervention Type BIOLOGICAL

Humira

Anti-inflammatory agents

Intervention Type BIOLOGICAL

Other Intervention Names

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Adalimumab Adalimumab

Eligibility Criteria

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Inclusion Criteria

1. 20-45 years old healthy males
2. Body mass index 19.0 \~ 28.0 kg/m2

Exclusion Criteria

1. Diagnosis of current or latent tuberculosis (TB); history of severe active chronic or local infection including TB
2. Severe infection (e.g. sepsis) requiring admission or antibiotics treatment within four weeks prior to administration
3. Clinically relevant previous or concomitant disease including hepatic, renal, neurological, respiratory, gastrointestinal, endocrine, hematologic, oncologic, cardiovascular, urinary, musculoskeletal or psychiatric, autoimmune disease/disorders
4. Chronic or relevant acute infections. A negative result for human immunodeficiency virus (HIV), Hepatitis B (Hep B), and hepatitis C (Hep C) is required for participation (i.e. HIV Ab, HBsAg, HBcAb, HCV Ab)
5. Fever greater than 38.3℃ within a week prior to administration of study drug
6. Previous or current drug abuse
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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LG Life Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kyung-Sang Yu, M.D., Ph.D., M.B.A

Role: PRINCIPAL_INVESTIGATOR

Dep. of Clnical Pharmacology, Seoul National University College of Medicine and Hospital

Other Identifiers

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LG-ALCL001

Identifier Type: -

Identifier Source: org_study_id

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