A Phase 3 Study of NI-071 in Patients With Rheumatoid Arthritis

NCT ID: NCT01927263

Last Updated: 2016-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

242 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2016-03-31

Brief Summary

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The purpose of this study is to investigate similarity between NI-071 and infliximab(the comparator) in terms of efficacy in patients with Rheumatoid Arthritis not adequately responding to Methotrexate.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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NI-071

Group Type EXPERIMENTAL

NI-071

Intervention Type BIOLOGICAL

100mg/vial

Infliximab

Group Type ACTIVE_COMPARATOR

Infliximab

Intervention Type BIOLOGICAL

100mg/vial

Interventions

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NI-071

100mg/vial

Intervention Type BIOLOGICAL

Infliximab

100mg/vial

Intervention Type BIOLOGICAL

Other Intervention Names

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Remicade

Eligibility Criteria

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Inclusion Criteria

1. Patients with a diagnosis of RA as defined by the American College Rheumatology (ACR) and European League Against Rheumatism (EULAR) criteria (ACR/EULAR 2010)
2. Patients who received MTX treatment (6- 16mg/week) for 2 weeks for at least 12 weeks prior to the screening visit

Exclusion Criteria

1. Patients with a following past History or concomitant diseases

* Other Connective tissue disorders which may interfere the efficacy assessment
* Chronic or recurrent infectious disease
* Demyelinating disease
* Congestive heart failure
* lymphoproliferative disorder or myelodysplastic syndrome
* Malignancy
* Interstitial lung disease
2. Patients with active or latent tuberculosis or history of tuberculosis
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nichi-Iko Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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NichiIko Investigational Site

Sendai, , Japan

Site Status

Countries

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Japan

Other Identifiers

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NI071F1(EFC13464)

Identifier Type: -

Identifier Source: org_study_id

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