Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2016-02-29
2017-12-31
Brief Summary
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The purpose of present study is to determine whether one week of HS intake affects microvascular reactivity in young healthy subjects without changes in BP. In addition, the investigators sought to evaluate if potential HS diet-induced microvascular dysfunction is associated with changes in oxidative stress level and/or with modification of immunological response in young healthy subjects.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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low salt diet
All subjects will be instructed to maintain a low-sodium (LS) diet, with an intake of less than 2.3 g of salt per day (DASH eating plan; US Department of Health and Human Services, 2006) for 7 days (washout period).
Low Salt (LS) diet
Intake of less than 2.3 g of salt per day for 7 days.
high salt diet
After washout period, all subjects will be instructed to maintain a high-sodium (HS) diet, with an intake of 11.2 g of salt per day for 7 days.
High Salt (HS) diet
Intake of 11.2 g of salt per day for 7 days.
Interventions
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Low Salt (LS) diet
Intake of less than 2.3 g of salt per day for 7 days.
High Salt (HS) diet
Intake of 11.2 g of salt per day for 7 days.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* drugs that could affect the endothelium
* hypertension
* coronary artery disease
* diabetes
* hyperlipidaemia
* renal impairment
* cerebrovascular and peripheral artery disease
18 Years
25 Years
ALL
Yes
Sponsors
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Josip Juraj Strossmayer University of Osijek
OTHER
Responsible Party
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Ines Drenjancevic
Vice Dean for Science, Faculty of Medicine Josip Juraj Strossmayer University of Osijek
Principal Investigators
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Ines Drenjancevic, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Faculty of Medicine, University of Osijek, Croatia
Locations
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Faculty of Medicine Osijek, Laboratory for Clinical and Sport Physiology
Osijek, , Croatia
Countries
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Central Contacts
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Facility Contacts
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References
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Cavka A, Cosic A, Jukic I, Jelakovic B, Lombard JH, Phillips SA, Seric V, Mihaljevic I, Drenjancevic I. The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans. J Physiol. 2015 Dec 15;593(24):5313-24. doi: 10.1113/JP271631. Epub 2015 Dec 7.
Cavka A, Cosic A, Grizelj I, Koller A, Jelakovic B, Lombard JH, Phillips SA, Drenjancevic I. Effects of AT1 receptor blockade on plasma thromboxane A2 (TXA2) level and skin microcirculation in young healthy women on low salt diet. Kidney Blood Press Res. 2013;37(4-5):432-42. doi: 10.1159/000355723. Epub 2013 Oct 13.
Cavka A, Jukic I, Ali M, Goslawski M, Bian JT, Wang E, Drenjancevic I, Phillips SA. Short-term high salt intake reduces brachial artery and microvascular function in the absence of changes in blood pressure. J Hypertens. 2016 Apr;34(4):676-84. doi: 10.1097/HJH.0000000000000852.
Other Identifiers
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215861071012
Identifier Type: -
Identifier Source: org_study_id
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