Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
133 participants
INTERVENTIONAL
2005-03-31
2012-11-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
DOUBLE
Study Groups
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High Sodium
High sodium
High sodium
Low sodium
Low sodium
Low sodium
Interventions
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High sodium
Low sodium
Eligibility Criteria
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Inclusion Criteria
2. 18-35 years of age,
3. No personal or first degree relative with hypertension or diabetes,
4. Blood pressure \<130/85 mmHg and \> 90/60 at the screening visit,
5. Body mass index \<30 kg/m2,
6. No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).
Exclusion Criteria
2. Smoking,
3. Recreational drug use,
4. Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months,
5. Prescription or herbal medication use,
6. Ischemic changes on resting electrocardiogram,
7. Known hypersensitivity to any of the study drugs,
8. Other active medical problems detected by examination or laboratory testing.
18 Years
35 Years
MALE
Yes
Sponsors
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Brigham and Women's Hospital
OTHER
Responsible Party
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Rhonda Bentley-Lewis, MD
Assistant Professor of Medicine
Principal Investigators
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Rhonda Bentley-Lewis, MD
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, United States
Countries
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Other Identifiers
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2004P002705
Identifier Type: -
Identifier Source: org_study_id