Computerized Cognitive Training in Epilepsy

NCT ID: NCT02726191

Last Updated: 2017-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2018-04-30

Brief Summary

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The purpose of this randomized uncontrolled single-site trial is to evaluate the efficacy of two novel computerized cognitive enhancing software packages for improving cognitive and behavioral outcomes in patients with epilepsy.

Detailed Description

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The proposed investigation will be the first to pit two software packages against each other to evaluate the relative efficacy and feasibility of their use among patients with epilepsy. Pharmacotherapy fails to control seizures in approximately 30% of patients. Use of non-pharmacologic interventions, such as cognitive rehabilitation, has shown some benefit for improving cognitive functions and reducing mood symptoms. Each of the computer exercises employ a set of stimuli that are generalizable and mimic real-world experiences.

Conditions

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Epilepsy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Posit Science

Group Type EXPERIMENTAL

Spatial Match Exercise

Intervention Type BEHAVIORAL

Temporal Sequence Reconstruction Exercise

Intervention Type BEHAVIORAL

Token Task Exercise

Intervention Type BEHAVIORAL

Story Recall Exercise

Intervention Type BEHAVIORAL

Sample-Match (Within Modality) Exercise

Intervention Type BEHAVIORAL

Pair-Match (Across-Modality) Exercise

Intervention Type BEHAVIORAL

Triad-FiguresExercise

Intervention Type BEHAVIORAL

Lumosity

Group Type EXPERIMENTAL

Monster Garden Exercise

Intervention Type BEHAVIORAL

Memory Match Exercise

Intervention Type BEHAVIORAL

Memory Matrix Exercise

Intervention Type BEHAVIORAL

Familiar Faces Exercises

Intervention Type BEHAVIORAL

Lost in Migration Exercise

Intervention Type BEHAVIORAL

Playing Koi Exercise

Intervention Type BEHAVIORAL

Interventions

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Spatial Match Exercise

Intervention Type BEHAVIORAL

Temporal Sequence Reconstruction Exercise

Intervention Type BEHAVIORAL

Token Task Exercise

Intervention Type BEHAVIORAL

Story Recall Exercise

Intervention Type BEHAVIORAL

Sample-Match (Within Modality) Exercise

Intervention Type BEHAVIORAL

Pair-Match (Across-Modality) Exercise

Intervention Type BEHAVIORAL

Triad-FiguresExercise

Intervention Type BEHAVIORAL

Monster Garden Exercise

Intervention Type BEHAVIORAL

Memory Match Exercise

Intervention Type BEHAVIORAL

Memory Matrix Exercise

Intervention Type BEHAVIORAL

Familiar Faces Exercises

Intervention Type BEHAVIORAL

Lost in Migration Exercise

Intervention Type BEHAVIORAL

Playing Koi Exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
* Must own a computer or have access to the internet.

Exclusion Criteria

* Full Scale IQ \< 80, as assessed by the WASI-II.
* History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Parkinson's disease, multiple sclerosis, dementia, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
* History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
* Visual or auditory impairment, which precludes participation in part, or all of the testing.
* English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for \>10 years.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stella Karantzoulis, MD

Role: PRINCIPAL_INVESTIGATOR

New York University Medical School

Locations

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New York University School of Medicine

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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15-00398

Identifier Type: -

Identifier Source: org_study_id

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