Computerized Cognitive Training for Patients With Epilepsy

NCT ID: NCT03644082

Last Updated: 2021-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-31

Study Completion Date

2021-04-30

Brief Summary

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This is a study on the effectiveness of computerized cognitive training for treatment of memory disorders in patients with epilepsy. Participants will be recruited from patients referred for neuropsychological assessment through the NYU Comprehensive Epilepsy Center's inpatient and outpatient services. Individuals meeting inclusion criteria will be screened for the presence of memory disturbance (defined by results of neuropsychological testing) and lack of exposure to any previous form of computerized cognitive training. All eligible subjects will be provided with an account for Lumosity with instructions to complete training modules 5 days per week for a total of 8 consecutive weeks. Outcomes will be evaluated through changes on the neuropsychological test battery.

Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Epilepsy Patients

Group Type EXPERIMENTAL

Luminosity Trial Memory Match

Intervention Type BEHAVIORAL

Working memory task that has users indicate whether the current symbol matches the one presented 2 symbols previously. As the user makes correct responses, the previous symbols reduce in contrast and fade int the background, ultimately disappearing, forcing the user to rely entirely on working memory to achieve success

Luminosity Trial Memory Matrix

Intervention Type BEHAVIORAL

The purpose id to remember the location of squares on a grid

Luminosity Trial Famliar Faces

Intervention Type BEHAVIORAL

The purpose is to create associations between visual and verbal information

Luminosity Trial Brain Shift

Intervention Type BEHAVIORAL

The purpose is to decide whether or not cards with numbers and letters are either even or vowels. This measures inhibition, flexibility, and monitoring response set. Also, letterfluency, category fluency, and category switching.

Luminosity Trial Star Search

Intervention Type BEHAVIORAL

The purpose is to visually scan several different objects and find the different object in array of pictures. This measures selective attention.

Luminosity Trial Word Bubbles

Intervention Type BEHAVIORAL

The purpose is to decide what suffix to use in order to complete a word whena prefix is given. The subject needs to come up with he ending of three different prefixes to complete the word.

This task measures verbal modality, deductive reasoning, integration of multiple bits of information, and flexibility of thinking.

Luminosity Trial Color Match

Intervention Type BEHAVIORAL

The purpose is to identify whether colors and words match each other. This measures the ability to inhibit a dominant and automatic verbal response

Luminosity Trial Ebb and Flow

Intervention Type BEHAVIORAL

Identify which direction leaves are pointing or moving depending on their color.This measures inhibition of impulsive and perseverative responding, and the ability to establish and maintain instructional set.

Luminosity TrialChalk Board Challenge

Intervention Type BEHAVIORAL

purpose is to problem solve quantitative reasoningequationsand to decide which card is greater or if the 2 cards are equal when the math problem is solved.

Luminosiuty Follow that Frog

Intervention Type BEHAVIORAL

The purposeis to remember the path a red frog takes as it jump from lilypad to lily pad in a pond. This measures flexibility of thinking on a visual-motor sequencing task and working memory

Luminosity Train of Thought

Intervention Type BEHAVIORAL

purpose is to guide specific colored trains into corresponding colored matching houses by attending to the different tracks. This measures divided attention.

Interventions

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Luminosity Trial Memory Match

Working memory task that has users indicate whether the current symbol matches the one presented 2 symbols previously. As the user makes correct responses, the previous symbols reduce in contrast and fade int the background, ultimately disappearing, forcing the user to rely entirely on working memory to achieve success

Intervention Type BEHAVIORAL

Luminosity Trial Memory Matrix

The purpose id to remember the location of squares on a grid

Intervention Type BEHAVIORAL

Luminosity Trial Famliar Faces

The purpose is to create associations between visual and verbal information

Intervention Type BEHAVIORAL

Luminosity Trial Brain Shift

The purpose is to decide whether or not cards with numbers and letters are either even or vowels. This measures inhibition, flexibility, and monitoring response set. Also, letterfluency, category fluency, and category switching.

Intervention Type BEHAVIORAL

Luminosity Trial Star Search

The purpose is to visually scan several different objects and find the different object in array of pictures. This measures selective attention.

Intervention Type BEHAVIORAL

Luminosity Trial Word Bubbles

The purpose is to decide what suffix to use in order to complete a word whena prefix is given. The subject needs to come up with he ending of three different prefixes to complete the word.

This task measures verbal modality, deductive reasoning, integration of multiple bits of information, and flexibility of thinking.

Intervention Type BEHAVIORAL

Luminosity Trial Color Match

The purpose is to identify whether colors and words match each other. This measures the ability to inhibit a dominant and automatic verbal response

Intervention Type BEHAVIORAL

Luminosity Trial Ebb and Flow

Identify which direction leaves are pointing or moving depending on their color.This measures inhibition of impulsive and perseverative responding, and the ability to establish and maintain instructional set.

Intervention Type BEHAVIORAL

Luminosity TrialChalk Board Challenge

purpose is to problem solve quantitative reasoningequationsand to decide which card is greater or if the 2 cards are equal when the math problem is solved.

Intervention Type BEHAVIORAL

Luminosiuty Follow that Frog

The purposeis to remember the path a red frog takes as it jump from lilypad to lily pad in a pond. This measures flexibility of thinking on a visual-motor sequencing task and working memory

Intervention Type BEHAVIORAL

Luminosity Train of Thought

purpose is to guide specific colored trains into corresponding colored matching houses by attending to the different tracks. This measures divided attention.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
* Presence of memory disturbance, as defined by an immediate or delayed memory index score \< 85 on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
* Availability of a home computer and internet for access to the computer training program.

Exclusion Criteria

* Full Scale IQ \< 80, as assessed by an appropriate Wechsler scale (WAIS-IV or WASI-II).
* Epilepsy surgery within 8 weeks of the beginning of the trial.
* History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Alzheimer's disease, multiple sclerosis, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
* History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia or bipolar disorder). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
* Visual or auditory impairment, which precludes participation in part, or all of the testing or computer training.
* English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for \>10 years.
* Previous exposure (\> one week) to Lumosity or a similar computerized training program.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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William Barr, MD

Role: STUDY_DIRECTOR

NYU Langone Health

Locations

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New York University School of Medicine

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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17-01830

Identifier Type: -

Identifier Source: org_study_id

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