Bioavailability Study of Pregabalin Extended Release Formulation With Various Release Rates in Healthy Volunteers

NCT ID: NCT02725112

Last Updated: 2021-01-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-02-12
• Study Completion Date: 2016-06-17

Brief Summary

This study is a Phase 1, randomized, open label, single dose, 6 treatment, 6 period, 6 sequence study in healthy adult volunteers. A total of 24 (4 in each treatment sequence) healthy male and female subjects who, at the time of screening, are between the ages of 18 and 55 years, inclusive will be enrolled. Subjects who discontinue from the study may be replaced at the Sponsor's discretion. Screening activities will be completed within approximately 28 days prior to Day 1 of Period 1. Subjects will be randomized to 1 of the 6 treatment sequences as described in Table 1 below. Each treatment sequence will consist of 6 periods with subjects receiving single doses of pregabalin ER 330 mg target release rate tablet, pregabalin ER 330 mg slow release rate tablet, pregabalin ER 330 mg fast release rate tablet, pregabalin IR 300 mg capsule, pregabalin ER 82.5 mg target release rate tablet, and pregabalin ER 330 mg aberrant fast release rate tablet formulations. All study treatments will be administered following a 600- 750 calorie, 30% fat evening meal.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Pregabalin ER- Target Release 330mg

A: Pregabalin ER tablet formulation, Target release rate, 1 x 330 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

A: Pregabalin ER tablet formulation, Target release rate, 1 x 330 mg, Oral.

Pregabalin ER - Slow Release 330mg

B: Pregabalin ER tablet formulation, Slow release rate, 1 x 330 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

B: Pregabalin ER tablet formulation, Slow release rate, 1 x 330 mg, Oral.

Pregabalin ER - Fast Release 330mg

C: Pregabalin ER tablet formulation, Fast release rate, 1 x 330 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

C: Pregabalin ER tablet formulation, Fast release rate, 1 x 330 mg, Oral.

Pregabalin IR - 300mg

D: Pregabalin IR capsule formulation, 1 x 300 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

D: Pregabalin IR capsule formulation, 1 x 300 mg, Oral.

Pregabalin ER - Target Release 82.5mg

E: Pregabalin ER tablet formulation, Target release rate, 1 x 82.5 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

E: Pregabalin ER tablet formulation, Target release rate, 1 x 82.5 mg, Oral.

Pregabalin ER - Aberrant Fast 330mg

F: Pregabalin ER tablet formulation, Aberrant fast release rate, 1 x 330 mg, Oral.

Group Type: EXPERIMENTAL

Pregabalin ER

Intervention Type: DRUG

F: Pregabalin ER tablet formulation, Aberrant fast release rate, 1 x 330 mg, Oral.

Interventions

Pregabalin ER

A: Pregabalin ER tablet formulation, Target release rate, 1 x 330 mg, Oral.

Intervention Type: DRUG

Pregabalin ER

B: Pregabalin ER tablet formulation, Slow release rate, 1 x 330 mg, Oral.

Intervention Type: DRUG

Pregabalin ER

C: Pregabalin ER tablet formulation, Fast release rate, 1 x 330 mg, Oral.

Intervention Type: DRUG

Pregabalin ER

D: Pregabalin IR capsule formulation, 1 x 300 mg, Oral.

Intervention Type: DRUG

Pregabalin ER

E: Pregabalin ER tablet formulation, Target release rate, 1 x 82.5 mg, Oral.

Intervention Type: DRUG

Pregabalin ER

F: Pregabalin ER tablet formulation, Aberrant fast release rate, 1 x 330 mg, Oral.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Healthy female subjects and/or male subjects who, at the time of screening, are between the ages of 18 and 55 years, inclusive. Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12 lead electrocardiogram (ECG) or clinical laboratory tests. A 1:1 ratio of men to women is desirable, but it will not be considered a protocol deviation if this is not met.

2. Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).

3. Evidence of a personally signed and dated informed consent document.

4. Subjects who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures.

Exclusion Criteria

1. Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing).

2. History of febrile illness within 5 days prior to the first dose of study investigational product.

3. Subjects with an estimated CLcr <60 mL/min derived using the method of Crockcroft and Gault.1

4. Any condition possibly affecting drug absorption.

5. A positive urine drug screen.

6. Use of tobacco or nicotine containing products in excess of the equivalent of 5 cigarettes per day.

7. History of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for males (1 drink = 5 ounces [150 mL] of wine or 12 ounces [360 mL] of beer or 1.5 ounces [45 mL] of hard liquor) within 6 months of Screening.

8. Treatment with an investigational drug within 30 days or 5 half lives preceding the first dose of study investigational product (whichever is longer).

9. Screening supine blood pressure >= 140 mm Hg (systolic) or >= 90 mm Hg (diastolic), following at least 5 minutes of supine rest. If blood pressure is >= 140 mm Hg (systolic) or >= 90 mm Hg (diastolic), the blood pressure should be repeated 2 more times and the average of the 3 blood pressure values should be used to determine the subject's eligibility.

10. Screening supine 12 lead ECG demonstrating QTc (time from ECG Q wave to the end of the T wave corresponding to electrical systole [QT] corrected for the heart rate) >450 msec or a QRS interval (time from ECG Q wave to the end of the S wave corresponding to ventricle depolarization) >120 msec. If QTc exceeds 450 msec, or QRS exceeds 120 msec, the ECG should be repeated 2 more times and the average of the 3 QTc or QRS values should be used to determine the subject's eligibility.

11. Pregnant female subjects; breastfeeding female subjects; male subjects with partners currently pregnant; male subjects able to father children and female subjects of childbearing potential who are unwilling or unable to use a highly effective method of contraception as outlined in this protocol for the duration of the study and for at least 28 days after the last dose of investigational product.

12. Use of prescription (other than oral, transdermal, intrauterine, implanted, or injected contraceptives or hormone replacement therapy) or nonprescription drugs and dietary supplements within 7 days or 5 half lives (whichever is longer) prior to the first dose of study medication.investigational product. Herbal supplements must be discontinued at least 28 days prior to the first dose of study medicationinvestigational product. As an exception, acetaminophen/paracetamol may be used at doses of greater than 1 g/day. Limited use of non prescription medications that are not believed to affect subject safety or the overall results of the study may be permitted on a case by case basis following approval by the Sponsor.

13. Blood donation (excluding plasma donations) of approximately 1 pint (500 mL) or more within 56 days prior to dosing.

14. History of sensitivity to pregabalin, gabapentin, or other alpha2 delta ligands.

15. History of sensitivity to heparin or heparin induced thrombocytopenia.

16. Unwilling or unable to comply with the Lifestyle Guidelines described in this protocol.

17. Previous participation in a study involving pregabalin.

18. Subjects who are investigational site staff members directly involved in the study, their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees directly involved in the study.

19. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

Pfizer New Haven Clinical Research Unit

New Haven, Connecticut, United States

Countries

United States

Related Links

https://trialinfoemail.pfizer.com/pages/landing.aspx?StudyID=A0081309&StudyName=A%20Phase%201%2C%20Randomized%2C%20Open-label%2C%20Single-dose%2C%205-period%20Study%20To%20Investigate%20The%20Effect%20Of%20In%20Vitro%20Dissolution%20Rate%20On%20The%20In%20Vivo%20Bioavailability%20Of%20Extended%20Release%20Formulations%20Of%20Pregabalin%20In%20Healthy%20Volunteers

To obtain contact information for a study center near you, click here.

https://trialinfoemail.pfizer.com/pages/landing.aspx?StudyID=A0081309&StudyName=A+Phase+1%2C+Randomized%2C+Open-label%2C+Single-dose%2C+6-period+Study+To+Investigate+The+Effect+Of+In+Vitro+Dissolution+Rate+On+The+In+Vivo+Bioavailability+Of+Extended+Release+Formulations+Of+Pregabalin+In+Healthy+Volunteers

To obtain contact information for a study center near you, click here.

Other Identifiers

A0081309

Identifier Type: -

Identifier Source: org_study_id