Safety and Efficacy Study of Pregabalin in Fibromyalgia

NCT ID: NCT00151489

Last Updated: 2021-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1020 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-04-30

Study Completion Date

2006-06-30

Brief Summary

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The purpose of this research study of pregabalin and fibromyalgia is to see if 1. pregabalin reduces the pain of fibromyalgia and if this effect lasts for six months and 2. to see if different dosages work better (reduce pain and mild to no side effects) for different people.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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pregabalin

Intervention Type DRUG

placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* At screening (V1), patients must meet the American College of Rheumatology criteria for fibromyalgia (i.e. widespread pain present for at least 3 months, and pain in at least 11 of 18 specific tender point sites
* At Screen (V1) and enrollment (V2), patients must have a score of greater than 40 mm on the Pain Visual Analog Scale

Exclusion Criteria

* Other severe pain or inflammatory muscle or rheumatologic disease other than fibromyalgia, active infections or untreated endocrine disorders; or severe depression and other serious hepatic, respiratory, hematologic or immunologic illness or active malignancy or history of malignancy (examples of prohibited diseases: Hepatitis C, HIV, diabetes with nerve pain, other nerve pain (shingles), sleep apnea, epilepsy, narcolepsy, rheumatoid arthritis, generalized osteoarthritis, Lupus, Lyme disease unless sign and symptom free for 2 years, Sjogren's Syndrome, Sarcoid, Psoriatic Arthritis, Scleroderma)
* Previous participation in a clinical trial with pregabalin; currently receiving or pending disability claims or workmans compensation or civil litigation, or used other experimental medicines within 30 days of screening
* Creatinine Clearance less than 60 mL/min (estimated from serum creatinine; low platelet and/or white blood cell counts; abnormal Westergren erythrocyte sedimentation rate; abnormal antinuclear antibody (ANA greater than 3U), or rheumatoid factor (RF greater than 80 IU/mL); abnormal (clinically relevant 12 lead ECG)
* Use of prohibited pain/sleep medications (including antidepressants, sedatives, hypnotics, NSAIDs, opiates, muscle relaxants) during the study. Washout required prior to study entry.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Anniston, Alabama, United States

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Birmingham, Alabama, United States

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Calera, Alabama, United States

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Huntsville, Alabama, United States

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Tuscaloosa, Alabama, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Scottsdale, Arizona, United States

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Fayetteville, Arkansas, United States

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Hot Springs, Arkansas, United States

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Anaheim, California, United States

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Carmichael, California, United States

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Fresno, California, United States

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Los Alamitos, California, United States

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Northridge, California, United States

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Pismo Beach, California, United States

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Santa Ana, California, United States

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Walnut Creek, California, United States

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Whittier, California, United States

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Denver, Colorado, United States

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Stratford, Connecticut, United States

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Newark, Delaware, United States

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Washington D.C., District of Columbia, United States

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Chiefland, Florida, United States

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Clearwater, Florida, United States

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Kissimmee, Florida, United States

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Miami, Florida, United States

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Ocala, Florida, United States

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Ocala, Florida, United States

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Palm Harbor, Florida, United States

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Palm Springs, Florida, United States

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Plantation, Florida, United States

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Plantation, Florida, United States

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St. Petersburg, Florida, United States

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Sunrise, Florida, United States

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Tampa, Florida, United States

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West Palm Beach, Florida, United States

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Atlanta, Georgia, United States

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Gurnee, Illinois, United States

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Peoria, Illinois, United States

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Evansville, Indiana, United States

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Evansville, Indiana, United States

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Indianapolis, Indiana, United States

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Prairie Village, Kansas, United States

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Lexington, Kentucky, United States

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Lexington, Kentucky, United States

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Lexington, Kentucky, United States

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Owensboro, Kentucky, United States

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Baton Rouge, Louisiana, United States

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New Orleans, Louisiana, United States

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New Orleans, Louisiana, United States

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Springfield, Massachusetts, United States

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Worcester, Massachusetts, United States

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Kalamazoo, Michigan, United States

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Lansing, Michigan, United States

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Edina, Minnesota, United States

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Jackson, Mississippi, United States

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Blue Springs, Missouri, United States

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Springfield, Missouri, United States

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Henderson, Nevada, United States

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Cherry Hill, New Jersey, United States

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Edison, New Jersey, United States

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Highland Park, New Jersey, United States

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Ridgewood, New Jersey, United States

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South Eddison, New Jersey, United States

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Albany, New York, United States

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Johnson City, New York, United States

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Rochester, New York, United States

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Smithtown, New York, United States

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Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Raleigh, North Carolina, United States

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Raleigh, North Carolina, United States

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Salisbury, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Mogadore, Ohio, United States

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Toledo, Ohio, United States

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Tulsa, Oklahoma, United States

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Eugene, Oregon, United States

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Medford, Oregon, United States

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Bensalem, Pennsylvania, United States

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Mechanicsburg, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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West Reading, Pennsylvania, United States

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Charleston, South Carolina, United States

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Greenville, South Carolina, United States

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Greer, South Carolina, United States

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Sioux Falls, South Dakota, United States

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Memphis, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Fort Worth, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Layton, Utah, United States

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Layton, Utah, United States

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Salt Lake City, Utah, United States

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South Jordan, Utah, United States

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Virginia Beach, Virginia, United States

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Virginia Beach, Virginia, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Spokane, Washington, United States

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Yakima, Washington, United States

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Charleston, West Virginia, United States

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Countries

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United States

References

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Pauer L, Atkinson G, Murphy TK, Petersel D, Zeiher B. Long-term maintenance of response across multiple fibromyalgia symptom domains in a randomized withdrawal study of pregabalin. Clin J Pain. 2012 Sep;28(7):609-14. doi: 10.1097/AJP.0b013e31823dd315.

Reference Type DERIVED
PMID: 22688598 (View on PubMed)

Related Links

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Other Identifiers

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A0081059

Identifier Type: -

Identifier Source: org_study_id

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