Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia

NCT ID: NCT01270828

Last Updated: 2021-01-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

806 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2014-11-30

Brief Summary

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The purpose of the study is to explore the safety and efficacy of a new once a day pregabalin formulation versus placebo for patients with post herpetic neuralgia (Shingles)

Detailed Description

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Conditions

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Post Herpetic Neuralgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Pregablain CR tablet 82.5 to 660mg

Group Type EXPERIMENTAL

Pregabalin

Intervention Type DRUG

Tablets, 82.5 to 660mg, once per day. Duration: 19 weeks

Placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

Placebo, 82.5 to 660mg, once per day. Duration: 13 weeks

Interventions

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Pregabalin

Tablets, 82.5 to 660mg, once per day. Duration: 19 weeks

Intervention Type DRUG

placebo

Placebo, 82.5 to 660mg, once per day. Duration: 13 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients must have pain present for more than 3 months after the healing of the herpes zoster skin rash.
* At screening (V1) and enrollment (V2), patients must have a score of greater than or equal to 4 on the Pain Numeric Rating Scale (1 week recall period).
* At enrollment (V2), at least 4 pain diaries must be completed satisfactorily within the last 7 days and the average pain score must be greater than or equal to 4.
* Male or female of any race, at least 18 years of age, and using appropriate methods of contraception

Exclusion Criteria

* Creatinine clearance \<30 mL/min (estimated from serum creatinine).
* Skin conditions in the affected dermatome that could alter sensation
* Pregabalin use in the last 30 days. Subjects taking pregabalin in the last 30 days should be washed out of pregabalin for at least 30 days prior to screening visit. Patients who had not responded to pregabalin
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Fundamental Research

Gulf Shores, Alabama, United States

Site Status

Radiant Research, Inc.

Chandler, Arizona, United States

Site Status

Elite Clinical Studies, LLC

Phoenix, Arizona, United States

Site Status

HOPE Research Institute

Phoenix, Arizona, United States

Site Status

The Pain Center of Arizona

Phoenix, Arizona, United States

Site Status

The Pain Center of Arizona

Phoenix, Arizona, United States

Site Status

Genova Clinical Research

Tucson, Arizona, United States

Site Status

Larry Watkins, M.D. (Private Practice)

Little Rock, Arkansas, United States

Site Status

Lynn Institute of the Ozarks

Little Rock, Arkansas, United States

Site Status

Hearne Family Practice Clinic

Little Rock, Arkansas, United States

Site Status

Center for Clinical Research, Inc

Carmichael, California, United States

Site Status

Community Medical Providers

Clovis, California, United States

Site Status

Sierra Medical Research

Clovis, California, United States

Site Status

Inland Pain Medicine

Colton, California, United States

Site Status

The Helm Center

Laguna Hills, California, United States

Site Status

University of Southern California

Los Angeles, California, United States

Site Status

USC IDS Pharmacy

Los Angeles, California, United States

Site Status

Translational Research Group, Inc

North Hollywood, California, United States

Site Status

George J. Rederich, M.D., Incorporated

Redondo Beach, California, United States

Site Status

Integrated Research Group, Inc.

Riverside, California, United States

Site Status

Drug Shipmnent Only Aristotelis T. Laliotis, M.D. Integrated Research Center, Inc.

San Diego, California, United States

Site Status

Integrated Research Center, Inc.

San Diego, California, United States

Site Status

Center For Clinical Research, Inc.

San Francisco, California, United States

Site Status

Neurological Research Institute

Santa Monica, California, United States

Site Status

Foothills Pain Management Clinic, PS

West Covina, California, United States

Site Status

JEM Research Institute

Atlantis, Florida, United States

Site Status

Orthopedic Research Institute

Boynton Beach, Florida, United States

Site Status

Innovative Research of West Florida, Inc.

Clearwater, Florida, United States

Site Status

Clinical Research of West Florida, Inc.

Clearwater, Florida, United States

Site Status

Clinical Physiology Associates

Fort Myers, Florida, United States

Site Status

Health Care Family Rehab & Research Center

Hialeah, Florida, United States

Site Status

Laszlo Jozsef Mate, MD

North Palm Beach, Florida, United States

Site Status

Family Care Specialists

Ocala, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

Compass Research, LLC

Orlando, Florida, United States

Site Status

Comprehensive Pain care of South Florida

Royal Palm Beach, Florida, United States

Site Status

Comprehensive Clinical Development Inc.

St. Petersburg, Florida, United States

Site Status

Neurology Clinical Research, Inc.

Sunrise, Florida, United States

Site Status

Clinical Research of West Florida, Inc.

Tampa, Florida, United States

Site Status

Meridien Research

Tampa, Florida, United States

Site Status

Injury Care Medical Center

Boise, Idaho, United States

Site Status

Millennium Pain Center, LLC

Bloomington, Illinois, United States

Site Status

(IP Shipping Address) Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

Site Status

Chicago Anesthesia Pain Specialists

Chicago, Illinois, United States

Site Status

Advanced Pain Care Clinic

Evansville, Indiana, United States

Site Status

Clinical Research Advantage

Evansville, Indiana, United States

Site Status

Global Scientific Innovations

Evansville, Indiana, United States

Site Status

Clinical Trials of America, Inc.

Monroe, Louisiana, United States

Site Status

Boston Clinical Trials

Boston, Massachusetts, United States

Site Status

Beacon Clinical Research

Brockton, Massachusetts, United States

Site Status

Infinity Medical Research, Inc.

North Dartmouth, Massachusetts, United States

Site Status

Michigan Head Pain & Neurological Institute

Ann Arbor, Michigan, United States

Site Status

QUEST Research Institute

Bingham Farms, Michigan, United States

Site Status

The Center for Pharmaceutical Research, PC

Kansas City, Missouri, United States

Site Status

Clinvest, A Division of Banyan Group, Inc

Springfield, Missouri, United States

Site Status

Medex Healthcare Research, Inc.

St Louis, Missouri, United States

Site Status

Montana Medical Research Inc

Missoula, Montana, United States

Site Status

Lincoln Internal Medicine Associates

Lincoln, Nebraska, United States

Site Status

Drug Shipment Only: Heartland Clinical Research, Inc.

Omaha, Nebraska, United States

Site Status

Heartland Clinical Research, Inc.

Omaha, Nebraska, United States

Site Status

The Office of Dr. Stephen H. Miller, MD

Las Vegas, Nevada, United States

Site Status

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, United States

Site Status

Dent Neurological Institute

Amherst, New York, United States

Site Status

SPRI Clinical Trials LLC

Brooklyn, New York, United States

Site Status

Medex Healthcare Research, Inc - Saint Louis

New York, New York, United States

Site Status

North American Partners In Pain Management

New York, New York, United States

Site Status

Asheville Neurology Specialists, PA

Asheville, North Carolina, United States

Site Status

Raleigh Neurology Associates, P.A.

Raleigh, North Carolina, United States

Site Status

The Center for Clinical Research

Winston-Salem, North Carolina, United States

Site Status

Radiant Research

Akron, Ohio, United States

Site Status

Providence Health Partners-Center for Clinical Research

Dayton, Ohio, United States

Site Status

Wells Institute for Health Awareness

Kettering, Ohio, United States

Site Status

Lynn Health Science Institute

Oklahoma City, Oklahoma, United States

Site Status

Mark A Fisher

Oklahoma City, Oklahoma, United States

Site Status

Pharmacorp Clinical Trials, Inc.

Charleston, South Carolina, United States

Site Status

Arlington Research Center, Inc.

Arlington, Texas, United States

Site Status

Lovelace Scientific Resources, Inc.

Austin, Texas, United States

Site Status

Radiant Research

Dallas, Texas, United States

Site Status

ClinRx Research, LLC

Richardson, Texas, United States

Site Status

Hillcrest Family Health Centers, Division of Clinical Research

Waco, Texas, United States

Site Status

Clinical Research Associates of Tidewater

Norfolk, Virginia, United States

Site Status

Clinical Investigation Specialists, Inc.

Kenosha, Wisconsin, United States

Site Status

DCC "St. Pantaleimon" OOD

Pleven, , Bulgaria

Site Status

MHAT-Pleven

Pleven, , Bulgaria

Site Status

MBALNP "Sveti Naum" EAD, Klinika po nervni bolesti za dvigatelni narushenia

Sofia, , Bulgaria

Site Status

Vtora Mnogoprofilna Bolnitsa za Aktivno Lechenie ¿ Sofia, AD, Sofia, Nevrologichno otdelenie

Sofia, , Bulgaria

Site Status

MBAL "Tokuda Bolnitsa", Otdelenie po nevrologiya

Sofia, , Bulgaria

Site Status

Universitetska mnogoprofilna bolnitsa za aktivno lechenie Aleksandrovska, Klinika po Nevrologia

Sofia, , Bulgaria

Site Status

Reumalab S.A.S

Medellín, Antioquia, Colombia

Site Status

Centro de Investigacion y Atencion Para la Salud Mental S.A. - CESAME

Bogota, Cundinamarca, Colombia

Site Status

Fundacion Cardiovascular de Colombia

Floridablanca, Santander Department, Colombia

Site Status

Opca bolnica Karlovac

Karlovac, Karlovacka Županija, Croatia

Site Status

Klinicki Bolnicki Centar Osijek

Osijek, Osjecko-baranjska Županija, Croatia

Site Status

Opca bolnica "Dr. Ivo Pedisic"

Sisak, Sisacko-moslavacka Županija, Croatia

Site Status

Neurologicka ambulance

Prerov I, , Czechia

Site Status

Aalborg Sygehus Nord

Aalborg, North Denmark, Denmark

Site Status

Glostrup Hospital

Glostrup Municipality, , Denmark

Site Status

Schmerzzentrum Frankfurt

Frankfurt am Main, Hesse, Germany

Site Status

pro scientia med im MARE Klinikum

Kiel-Kronshagen, Schleswig-Holstein, Germany

Site Status

DGS-Schmerzzentrum Eichstätt

Eichstätt, , Germany

Site Status

Family Medicine

Hong Kong, , Hong Kong

Site Status

Queen Elizabeth Hospital

Kowloon, , Hong Kong

Site Status

Medanta Institute of Neurosciences

Gurgaon, Haryana, India

Site Status

Manipal Hospital

Bangalore, Karnataka, India

Site Status

M. S. Ramaiah Medical College and Hospitals

Bangalore, Karnataka, India

Site Status

Mallikatta Neuro Centre

Mangalore, Karnataka, India

Site Status

Indraprastha Apollo Hospitals

New Delhi, , India

Site Status

"SYNEXUS POLSKA" Sp. z o.o.

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Prof. dr hab. med. Leszek Szepanski Prywatna Praktyka Lekarska Gabinet Reumatologiczny

Lublin, Lublin Voivodeship, Poland

Site Status

"SYNEXUS POLSKA" Sp. z o.o. Oddzial w Warszawie

Warsaw, Masovian Voivodeship, Poland

Site Status

Niepubliczny Zaklad Opieki Zdrowotnej "Przychodnia Morena" Sp. z o.o.

Gdansk, Pomeranian Voivodeship, Poland

Site Status

"SYNEXUS POLSKA" Sp. z o.o. Oddzial w Gdyni

Gdynia, Pomeranian Voivodeship, Poland

Site Status

"SYNEXUS POLSKA" Sp. z o.o. Oddzial w Katowicach

Katowice, Silesian Voivodeship, Poland

Site Status

State Budgetary Health Institution of Yaroslavl region "Clinical hospital #10"

Yaroslavl, Russian Federation, Russia

Site Status

State Budgetary Educational Institution for higher Professional Training "Kazan State Medical Univer

Kazan', Tatarstan, Respublika, Russia

Site Status

Kazan State Medical University

Kazan', Tatarstan, Respublika, Russia

Site Status

GBUZ Nizhny Novgorod Regional Clinical Hospital N.A. Semashko

Nizhny Novgorod, , Russia

Site Status

Clinic of Nervous Diseases M.I. Astvatsaturov

Saint Petersburg, , Russia

Site Status

St. Petersburg State Healthcare Institution City Hospital # 40 Kurortnogo Administrativnogo Rajona

Saint Petersburg, , Russia

Site Status

State Budgetary Educational Institution for Higher Professional Education

Smolensk, , Russia

Site Status

State Budgetary Educational Institution for Higher Professional Education

Smolensk, , Russia

Site Status

Clinic for Neurology

Belgrade, , Serbia

Site Status

Clinic for Neurology

Niš, , Serbia

Site Status

Euro-Neuro s.r.o., Neurologicka ambulancia

Bratislava, , Slovakia

Site Status

Univerzitna nemocnica Bratislava, Nemocnica sv. Cyrila a Metoda, Neurologicke oddelenie

Bratislava, , Slovakia

Site Status

MUDr. Eva Gasparova - neurologicka ambulancia

Hlohovec, , Slovakia

Site Status

Neurologicka ambulancia, Neuron-DT,s.r.o.

Žilina, , Slovakia

Site Status

Nelson Mandela Academic Hospital Research Unit

Mthatha, Eastern Cape, South Africa

Site Status

Iatros International

Bloemfontein, , South Africa

Site Status

Synapta Clinical Research Centre

Durban, , South Africa

Site Status

Mzansi Ethical Research Centre

Middelburg, , South Africa

Site Status

Jakaranda Pain Clinic

Pretoria, , South Africa

Site Status

Probare

Lund, Skåne County, Sweden

Site Status

Me3plus Clinical Trials

Gothenburg, , Sweden

Site Status

CTC, Sahlgrenska sjukhuset/SU

Gothenburg, , Sweden

Site Status

Center for Lakemedelsstudier

Malmo, , Sweden

Site Status

Bragee Medect AB

Stockholm, , Sweden

Site Status

Chang Gung Medical Foundation-Linkou Branch

Kwei Shan Town, Taoyuan County, Taiwan

Site Status

National Taiwan University Hospital (Neurology)

Taipei, , Taiwan

Site Status

Public Institution "Institute of Neurology, Psychiatry and Narcology of AMS of Ukraine"

Kharkiv, , Ukraine

Site Status

Kyiv City Clinical Hospital #4

Kyiv, , Ukraine

Site Status

Lviv NMU n.a. Danylo Galytskyy

Lviv, , Ukraine

Site Status

Regional Municipal Dermatovenerologic Dispensary

Lviv, , Ukraine

Site Status

Crimean Republican Institution "Clinical Dermatovenerologic Dispensary"

Simferopol, , Ukraine

Site Status

Municipal Establishment "Vinnitsa Regional Psychoneurological Hospital n.a. O.I. Yushchenko"

Vinnitsa, , Ukraine

Site Status

Municipal Establishment "City Clinical Hospital #2", Neurology Department

Zaporizhzhya, , Ukraine

Site Status

Countries

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United States Bulgaria Colombia Croatia Czechia Denmark Germany Hong Kong India Poland Russia Serbia Slovakia South Africa Sweden Taiwan Ukraine

References

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Huffman CL, Goldenberg JN, Weintraub J, Sanin L, Driscoll J, Yang R, Chew ML, Scavone JM. Efficacy and Safety of Once-Daily Controlled-Release Pregabalin for the Treatment of Patients With Postherpetic Neuralgia: A Double-Blind, Enriched Enrollment Randomized Withdrawal, Placebo-Controlled Trial. Clin J Pain. 2017 Jul;33(7):569-578. doi: 10.1097/AJP.0000000000000445.

Reference Type DERIVED
PMID: 27753650 (View on PubMed)

Related Links

Other Identifiers

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2009-016766-86

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

A0081224

Identifier Type: -

Identifier Source: org_study_id

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