Adolescent Fibromyalgia Study

NCT ID: NCT01020474

Last Updated: 2021-01-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

107 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2014-12-31

Brief Summary

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This study will compare pregabalin with placebo over a 15 week period in adolescents with fibromyalgia aged 12-17 years to evaluate the safety and efficacy of pregabalin.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

matching placebo capsules twice daily.

drug-pregabalin

Group Type EXPERIMENTAL

pregabalin (Lyrica)

Intervention Type DRUG

75-450mg/day pregabalin dose optimised at start of study

Interventions

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placebo

matching placebo capsules twice daily.

Intervention Type DRUG

pregabalin (Lyrica)

75-450mg/day pregabalin dose optimised at start of study

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of fibromyalgia
* 12-17 years of age

Exclusion Criteria

* Patients with other pain conditions
* Previous treatment with pregabalin
* Patients taking excluded medication
Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Childrens Hospital Los Angeles

Los Angeles, California, United States

Site Status

Apex Research Institute

Santa Ana, California, United States

Site Status

Eileen Messing, Psy D.

Delray Beach, Florida, United States

Site Status

Arthritis Associates of South Florida

Delray Beach, Florida, United States

Site Status

Delray Research Associates

Delray Beach, Florida, United States

Site Status

Florida Medical Center and Research, Inc.

Miami, Florida, United States

Site Status

Harmony Clinical Research, Incorporated

North Miami Beach, Florida, United States

Site Status

Rheumatology Associates of Central Florida, PA

Orlando, Florida, United States

Site Status

Medical Research & Health Education Foundation, Inc.

Columbus, Georgia, United States

Site Status

North Georgia Rheumatology, PC

Lawrenceville, Georgia, United States

Site Status

Kosair Charities Pediatric Clinical Research Unit

Louisville, Kentucky, United States

Site Status

Kosair Children's Hospital

Louisville, Kentucky, United States

Site Status

University of Louisville

Louisville, Kentucky, United States

Site Status

University Pediatric Rheumatology of Kentucky, LLC

Louisville, Kentucky, United States

Site Status

University of Massachusetts Memorial Medical Center Department of Pediatrics

Worcester, Massachusetts, United States

Site Status

A&A Pain Institute of St. Louis

St Louis, Missouri, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Duke Medicine Plaza

Raleigh, North Carolina, United States

Site Status

Akron Children's Hospital

Akron, Ohio, United States

Site Status

Akron Children's Hospital

Boardman, Ohio, United States

Site Status

Boardman Medical Pavilion

Boardman, Ohio, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

Site Status

Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status

The Research Institute at Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status

St. Christopher's Hospital for Children / Section of Rheumatology

Philadelphia, Pennsylvania, United States

Site Status

Medical University of South Carolina, Pediatric Rheumatology

Charleston, South Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

MUSC University Children's Hospital

Charleston, South Carolina, United States

Site Status

Carolina Research Center

Myrtle Beach, South Carolina, United States

Site Status

Fatigue Consultation Clinic

Salt Lake City, Utah, United States

Site Status

Bioregeneracni a rehabilitacni centrum

Říčany, , Czechia

Site Status

Krishna Institute of Medical Sciences Ltd

Secunderabad, Andhra Pradesh, India

Site Status

Mallikatta Neuro Centre

Mangalore, Karnataka, India

Site Status

Sushrut Hospital, Research Centre & Post Graduate Institute of Orthopaedics

Nagpur, Maharashtra, India

Site Status

Department of Physical Medicine & Rehabilitation

Lucknow, Uttar Pradesh, India

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Countries

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United States Czechia India Taiwan

References

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Arnold LM, Schikler KN, Bateman L, Khan T, Pauer L, Bhadra-Brown P, Clair A, Chew ML, Scavone J; Pregabalin Adolescent Fibromyalgia Study Group. Safety and efficacy of pregabalin in adolescents with fibromyalgia: a randomized, double-blind, placebo-controlled trial and a 6-month open-label extension study. Pediatr Rheumatol Online J. 2016 Jul 30;14(1):46. doi: 10.1186/s12969-016-0106-4.

Reference Type DERIVED
PMID: 27475753 (View on PubMed)

Related Links

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Other Identifiers

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2010-019521-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

A0081180

Identifier Type: -

Identifier Source: org_study_id

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