12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects

NCT ID: NCT01061372

Last Updated: 2021-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Clinical Phase

PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2011-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to assess efficacy and safety of pregabalin in treating moderate to severe Restless Legs Syndrome in comparison to placebo.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Restless Legs Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo, orally administered once a day, 1-3 hours before bedtime for 12 weeks

Pregabalin 150 mg/day

Group Type EXPERIMENTAL

pregabalin

Intervention Type DRUG

pregabalin 150 mg, orally administered once a day, 1- 3 hours before the bedtime for 12 weeks

Pregabalin 300 mg/day

Group Type EXPERIMENTAL

pregabalin

Intervention Type DRUG

pregabalin 300 mg, orally administered once a day, 1- 3 hours before the bedtime for 12 weeks

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Placebo

Placebo, orally administered once a day, 1-3 hours before bedtime for 12 weeks

Intervention Type DRUG

pregabalin

pregabalin 150 mg, orally administered once a day, 1- 3 hours before the bedtime for 12 weeks

Intervention Type DRUG

pregabalin

pregabalin 300 mg, orally administered once a day, 1- 3 hours before the bedtime for 12 weeks

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lyrica Lyrica

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Idiopathic Restless Legs Syndrome with the presence of all four clinical manifestations of RLS:
* RLS symptoms occur predominantly in the evening
* RLS history at least 6 months
* International Restless Legs Study Group Rating Scale (IRLS) greater than or equal to 15 at the beginning and the end of placebo run-in
* Have greater than or equal to 15 nights with RLS symptoms in the month prior to screening

Exclusion Criteria

* Any secondary RLS
* Current augmentation due to RLS treatment
* Placebo responders identified during the placebo run-in
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

A0081184

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Adolescent Fibromyalgia Study
NCT01020474 COMPLETED PHASE4