Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases

NCT ID: NCT02721524

Last Updated: 2016-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

86 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-30

Study Completion Date

2016-09-30

Brief Summary

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This study aims to compare whether De Vega's Suture annuloplasty is equally effective in reducing the progression of Functional Tricuspid regurgitation as that claimed for Ring annuloplasty in Rheumatic Heart Disease patients with concurrent Mitral valve replacement.

Detailed Description

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Functional Tricuspid regurgitation (FTR) occurs due to annular dilatation in association with left sided valve disease and is more commonly seen than primary pathology in patients with Rheumatic mitral valve disease. FTR occurs due to increased right ventricle after load that leads to either dilatation or geometric deformation of Tricuspid annulus. If left untreated, FTR may worsen and increase morbidity and mortality.

Conditions

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Functional Tricuspid Regurgitation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group R (ring)

Patients in Group R will undergo tricuspid ring annuloplasty

Group Type ACTIVE_COMPARATOR

Tricuspid Annuloplasty

Intervention Type PROCEDURE

Patients will undergo repair of tricuspid regurgitation

Group S (suture)

Patients in Group S will undergo De Vega's suture annuloplasty

Group Type ACTIVE_COMPARATOR

Tricuspid Annuloplasty

Intervention Type PROCEDURE

Patients will undergo repair of tricuspid regurgitation

Interventions

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Tricuspid Annuloplasty

Patients will undergo repair of tricuspid regurgitation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* The participants will be all patients between 15 to 75 years of age group diagnosed as a case of Rheumatic Mitral Valve disease with moderate to severe functional Tricuspid regurgitation.

Exclusion Criteria

* Patient with organic Tricuspid Valve (TV) lesion diagnosed in Echocardiography
* Patient with FTR requiring Mitral Valve repair
* Patient with FTR requiring concomitant aortic valve replacement
* Patient with FTR secondary to pathology other than Mitral valve disease
Minimum Eligible Age

14 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shahid Gangalal National Heart Centre

OTHER

Sponsor Role lead

Responsible Party

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Marisha Aryal

Resident, Cardiac Surgery Dept.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Marisha Aryal, MBBS

Role: PRINCIPAL_INVESTIGATOR

Shahid Gangalal National Heart Centre

Locations

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Shahid Gangalal National Heart Centre

Kathmandu, Bagmati, Nepal

Site Status RECRUITING

Countries

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Nepal

Central Contacts

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Binita Tamrakar, RN

Role: CONTACT

+97714371322 ext. 576

Facility Contacts

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Binita Tamrakar, RN

Role: primary

+97714371322 ext. 576

References

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Tang GH, David TE, Singh SK, Maganti MD, Armstrong S, Borger MA. Tricuspid valve repair with an annuloplasty ring results in improved long-term outcomes. Circulation. 2006 Jul 4;114(1 Suppl):I577-81. doi: 10.1161/CIRCULATIONAHA.105.001263.

Reference Type BACKGROUND
PMID: 16820641 (View on PubMed)

Guenther T, Mazzitelli D, Noebauer C, Hettich I, Tassani-Prell P, Voss B, Lange R. Tricuspid valve repair: is ring annuloplasty superior? Eur J Cardiothorac Surg. 2013 Jan;43(1):58-65; discussion 65. doi: 10.1093/ejcts/ezs266. Epub 2012 May 24.

Reference Type BACKGROUND
PMID: 22627660 (View on PubMed)

Sarralde JA, Bernal JM, Llorca J, Ponton A, Diez-Solorzano L, Gimenez-Rico JR, Revuelta JM. Repair of rheumatic tricuspid valve disease: predictors of very long-term mortality and reoperation. Ann Thorac Surg. 2010 Aug;90(2):503-8. doi: 10.1016/j.athoracsur.2010.03.105.

Reference Type BACKGROUND
PMID: 20667339 (View on PubMed)

Rivera R, Duran E, Ajuria M. Carpentier's flexible ring versus De Vega's annuloplasty. A prospective randomized study. J Thorac Cardiovasc Surg. 1985 Feb;89(2):196-203.

Reference Type BACKGROUND
PMID: 3881631 (View on PubMed)

Badano LP, Muraru D, Enriquez-Sarano M. Assessment of functional tricuspid regurgitation. Eur Heart J. 2013 Jul;34(25):1875-85. doi: 10.1093/eurheartj/ehs474. Epub 2013 Jan 9.

Reference Type BACKGROUND
PMID: 23303656 (View on PubMed)

Rogers JH, Bolling SF. The tricuspid valve: current perspective and evolving management of tricuspid regurgitation. Circulation. 2009 May 26;119(20):2718-25. doi: 10.1161/CIRCULATIONAHA.108.842773.

Reference Type RESULT
PMID: 19470900 (View on PubMed)

McCarthy PM, Bhudia SK, Rajeswaran J, Hoercher KJ, Lytle BW, Cosgrove DM, Blackstone EH. Tricuspid valve repair: durability and risk factors for failure. J Thorac Cardiovasc Surg. 2004 Mar;127(3):674-85. doi: 10.1016/j.jtcvs.2003.11.019.

Reference Type RESULT
PMID: 15001895 (View on PubMed)

Navia JL, Nowicki ER, Blackstone EH, Brozzi NA, Nento DE, Atik FA, Rajeswaran J, Gillinov AM, Svensson LG, Lytle BW. Surgical management of secondary tricuspid valve regurgitation: annulus, commissure, or leaflet procedure? J Thorac Cardiovasc Surg. 2010 Jun;139(6):1473-1482.e5. doi: 10.1016/j.jtcvs.2010.02.046. Epub 2010 Apr 14.

Reference Type RESULT
PMID: 20394950 (View on PubMed)

Other Identifiers

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TRICUSPID STUDY-RCT

Identifier Type: -

Identifier Source: org_study_id

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