Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Study Completion Date

2017-04-30

Brief Summary

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Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls.

Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method.

MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.

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Detailed Description

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Conditions

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Migraine With Aura

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Migraine with aura Patients

Patients with migraine with aura will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler.

Group Type OTHER

Magnetic resonance imaging

Intervention Type OTHER

Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.

Transcranial Doppler

Intervention Type OTHER

Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.

Controls

Control group with healthy volunteers will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler.

Group Type OTHER

Magnetic resonance imaging

Intervention Type OTHER

Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.

Transcranial Doppler

Intervention Type OTHER

Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.

Interventions

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Magnetic resonance imaging

Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.

Intervention Type OTHER

Transcranial Doppler

Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Migraine with aura patients : fulfilling the International Classification of Headache Disorders-3 beta criteria of MA
* Control group : Gender- and age-matched subjects without history of migraine with or without aura or any other headache

Exclusion Criteria

* History of illness or injury of central or peripherical nervous system
* Previous history of a disease potentially impairing cerebral autoregulation (diabetes, sleep apnea syndrome, uncontrolled hypertension, cardiac arrhythmia, hearth failure, carotid stenosis)
* Contraindications related to MRI
* Absence of temporal acoustic window
* Pregnancy

Minimum Eligible Age

30 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes