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Mitochondrial Function in Circulating Cells and Muscle Tissue

NCT ID: NCT02700698

Last Updated: 2021-12-01

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2018-05-01

Brief Summary

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The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.

Detailed Description

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Data from human and animal models strongly suggests that reduced tissue mitochondrial function can be an early marker for detection of dysfunctional metabolism. It is unclear if tissue mitochondrial dysfunction can be detected using less invasive methodology. In this project, the investigators plan to study mitochondrial bioenergetics in circulating cells and paired muscle biopsies in two metabolic disparate groups of women; healthy lean vs. overweight/obese with/without insulin resistant women of similar age. Women of similar age that are either healthy lean or overweight/obese with/without insulin resistance will be recruited to participate in one study that includes a blood draw and a muscle biopsy. Mitochondrial function in circulating blood cells and muscle tissue will be determined. The association between circulating blood cells and muscle tissue mitochondria respiration will be determined for the two groups combined, and differences between groups will also be investigated.

Conditions

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Healthy Obesity Insulin Sensitivity Women

Keywords

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Mitochondria women muscle PBMC

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy lean

Healthy lean women, 25-35 years

No interventions assigned to this group

Overweight/obese with/without IR

Overweight/obese with/without insulin resistant women, 25-35 years

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Women
* 25-35 years of age
* Either healthy lean (BMI\<25) or insulin resistant and obese (BMI \>30)

Exclusion Criteria

* Medication that can affect study outcomes, as determined by the principal investigator, including anti-diabetic medication
* Chronic diseases, acute inflammation, chronic renal failure (glomerular filtration rate \<45), or heart problems
Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Arkansas Children's Hospital Research Institute

OTHER

Sponsor Role collaborator

University of Arkansas

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elisabet Borsheim, PhD

Role: PRINCIPAL_INVESTIGATOR

Arkansas Children's Nutrition Center

Locations

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Arkansas Children's Nutrition Center

Little Rock, Arkansas, United States

Site Status

UAMS

Little Rock, Arkansas, United States

Site Status

Countries

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United States

References

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Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Borsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E503-E512. doi: 10.1152/ajpendo.00084.2019. Epub 2019 Jun 18.

Reference Type RESULT
PMID: 31211617 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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205139

Identifier Type: -

Identifier Source: org_study_id