Pre-eclampsia and Biochemical Markers

NCT ID: NCT02665897

Last Updated: 2017-06-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2017-05-31

Brief Summary

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In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.

This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.

Detailed Description

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Conditions

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Detection of Preeclampsia Complications

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Eclampsia

pregnant women with eclampsia will be diagnosed by the occurrence of seizures on top of preeclampsia.

No interventions assigned to this group

severe preeclampsia

pregnant women with severe preeclampsia will be diagnosed according to blood pressure ≥160/110 mmHg with proteinuria detection by boiling method +3,+4.

No interventions assigned to this group

healthy

matched normotensive pregnant women.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 20-40 years.
* Gestational age \>20 weeks.

Exclusion Criteria

* Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension.
* Patients Refuse to participate in the study
* Patients already have complicated preeclampsia.
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Mohamed Abbas

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ahmed Abbas

Assiut, Cairo Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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PET

Identifier Type: -

Identifier Source: org_study_id

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