Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

NCT ID: NCT00653809

Last Updated: 2012-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-06-30

Study Completion Date

2009-09-30

Brief Summary

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The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Detailed Description

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Conditions

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Preeclampsia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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A, 1, I

Caucasian women without preeclampsia or PIH, delivering their first child

No interventions assigned to this group

A, 1, II

Caucasian women with preeclampsia or PIH, delivering their first child

No interventions assigned to this group

A, 2, I

African-american women without preeclampsia or PIH, delivering their first child

No interventions assigned to this group

A, 2, II

African-American women with preeclampsia or PIH, delivering their first child

No interventions assigned to this group

B, 1, I

Caucasian women without preeclampsia or PIH, delivering at least their second child

No interventions assigned to this group

B, 1, II

Caucasian women with preeclampsia or PIH, delivering at least their second child

No interventions assigned to this group

B, 2, I

African-american women without preeclampsia or PIH, delivering at least their second child

No interventions assigned to this group

B, 2, II

African-american women with preeclampsia or PIH, delivering at least their second child

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* African-american or Caucasian
* Pregnant
* Between ages of 18 - 40 years of age

Exclusion Criteria

* Presence of a disease or condition which is not preeclampsia
* Drug or alcohol abuse during pregnancy
* Obesity
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Office of Minority Health

UNKNOWN

Sponsor Role collaborator

Mississippi Institute for Improvement of Geographic Minority Health

UNKNOWN

Sponsor Role collaborator

University of Mississippi Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Kedra Wallace

Postdoc Research Fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kedra L Wallace, PhD

Role: PRINCIPAL_INVESTIGATOR

Obstetrics & Gynecology

Locations

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University of MS Medical Center

Jackson, Mississippi, United States

Site Status

Countries

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United States

Other Identifiers

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2007-0065

Identifier Type: -

Identifier Source: org_study_id

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