Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels
NCT ID: NCT02652832
Last Updated: 2018-08-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
200 participants
INTERVENTIONAL
2010-12-31
2019-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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Depression Electroconvulsive therapy
40 patients with major depression receiving a mean of 12 sessions of Electroconvulsive therapy
non invasive brain stimulation
non invasive brain stimulation
Depression active repetitive transcranial magnetic stimulation
40 patients with major depression receiving a mean 4 weeks of 1 Hz repetitive transcranial magnetic stimulation applied over the right dorsolateral prefrontal cortex - DLPFC
non invasive brain stimulation
non invasive brain stimulation
Depression sham repetitive transcranial magnetic stimulation
40 patients with major depression receiving a mean 4 weeks of sham 1 Hz repetitive transcranial magnetic stimulation applied over the right dorsolateral prefrontal cortex - DLPFC
non invasive brain stimulation
non invasive brain stimulation
Schizophrenia active transcranial magnetic stimulati
40 patients with schizophrenia and predominant negative symptoms receiving 20 sessions of intermittent theta burst simulation (iTBS) applied over the left dorsolateral prefrontal cortex - DLPFC
non invasive brain stimulation
non invasive brain stimulation
Schizophrenia sham transcranial magnetic stimulation
patients with schizophrenia and predominant negative symptoms receiving 20 sessions of sham intermittent theta burst simulation (iTBS) applied over the left dorsolateral prefrontal cortex - DLPFC
non invasive brain stimulation
non invasive brain stimulation
Schizophrenia active transcranial Direct Current Stimulation
40 patients with schizophrenia and auditory verbal hallucinations receiving 10 sessions of transcranial Direct current stimulation (tDCS) applied with the anode over the left dorsolateral prefrontal cortex - DLPFC- and the cathode over the left temporoparietal junction
non invasive brain stimulation
non invasive brain stimulation
Schizophrenia sham transcranial Direct Current Stimulation
40 patients with schizophrenia and auditory verbal hallucinations receiving 10 sessions of sham transcranial Direct current stimulation (tDCS) applied with the anode over the left dorsolateral prefrontal cortex - DLPFC- and the cathode over the left temporoparietal junction
non invasive brain stimulation
non invasive brain stimulation
Healthy volunteers
80 healthy volunteers receiving no stimulation
No interventions assigned to this group
Interventions
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non invasive brain stimulation
non invasive brain stimulation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* in the schizophrenia group DSM IV criteria of schizophrenia; pharmaco-resistance of symptoms (either negative symptoms or auditory verbal hallucination); received rTMS or tDCS
* in the healthy volunteers group : to not have axis I of DSM IV diagnosis; no siblings with axis I DSM IV diagnosis
Exclusion Criteria
* pregnancy
* received benzodiazepine
In the depression and schizophrenia group:
* bipolar disorder
* other axis I of DSM IV diagnosis (excluding for Tobacco use disorder)
18 Years
ALL
Yes
Sponsors
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Hôpital le Vinatier
OTHER
Responsible Party
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Principal Investigators
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jerome brunelin, PhD
Role: STUDY_DIRECTOR
CH le vinatier
Locations
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Hopital Le vinatier
Bron, , France
Countries
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Central Contacts
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Facility Contacts
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emmanuel poulet, MD, PhD
Role: primary
Other Identifiers
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CSR B04
Identifier Type: -
Identifier Source: org_study_id
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