Transcranial Direct Current Stimulation (tDCS) and Hallucinations in Schizophrenia
NCT ID: NCT00870909
Last Updated: 2017-03-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
46 participants
INTERVENTIONAL
2009-02-02
2016-07-20
Brief Summary
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Detailed Description
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Using anodal \& cathodal tDCS the investigators aimed to treat auditory hallucinations, a symptoms of schizophrenia. The investigators plan to apply tDCS such that it can simultaneously increased activity in the frontal brain areas and reduce activity over temporoparietal cortex, 2 areas involved in the physiopathology of the disease. Real active stimulation will be compare to a sham condition in 60 patients (30 in each group). 30 patients will be included in a French center (Hospital le Vinatier, sponsor of the study) and 30 in Tunisia (laboratory "vulnerability to psychosis" (Pr Gaha) à Monastir).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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active tDCS
tDCS active; - Intensity = 2 milliamps (mA) during 20 minutes. ramp up/ramp down 30sec anodal tDCS applied over the left DLPFC combined with cathodal tDCS applied over the left temporoparietal junction (TPJ).
10 sessions, 2 per day
active tDCS
Intensity 2 mA during 20 minutes, 2 times per day
sham tDCS
tDCS placebo same electrode montage than in the active group. 30 sec of active tDCS in the beginning of the stimulation sessions; ramp up/ramp down 30 sec
sham tDCS
sham condition as delivered by the stimulator
Interventions
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active tDCS
Intensity 2 mA during 20 minutes, 2 times per day
sham tDCS
sham condition as delivered by the stimulator
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Auditory verbal hallucinations for at least 6 weeks (despite antipsychotic drugs)
* Medication Resistance according to Kane et al., 1988
* Age between 18 and 50 years old
* Informed consent
Exclusion Criteria
* Pregnant
18 Years
50 Years
ALL
No
Sponsors
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Hôpital le Vinatier
OTHER
Responsible Party
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Principal Investigators
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emmanuel poulet, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Hopital Le Vinatier
JEROME BRUNELIN, PhD
Role: STUDY_DIRECTOR
Hopital le Vinatier
Locations
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Hopital Le vinatier
Bron, , France
Laboratoire de Recherche " Vulnérabilité Aux Psychoses "
Monastir, , Tunisia
Countries
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References
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Brunelin J, Mondino M, Gassab L, Haesebaert F, Gaha L, Suaud-Chagny MF, Saoud M, Mechri A, Poulet E. Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry. 2012 Jul;169(7):719-24. doi: 10.1176/appi.ajp.2012.11071091.
Other Identifiers
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2008-A01226-49
Identifier Type: -
Identifier Source: org_study_id
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