Impact of Hepatitis C Virus Therapy on Central Nervous System Outcomes

NCT ID: NCT02650024

Last Updated: 2021-04-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 16 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-01-31
• Study Completion Date: 2021-04-30

Brief Summary

This study observes the effects of newly developed direct-acting antiviral (DAA) treatments on the central nervous system (CNS) of individuals with chronic Hepatitis C (HCV). The goals of this study are to determine the CNS impact of curing chronic HCV disease with newly established DAA therapies and how HIV alters this relationship.

Detailed Description

The specific aims of the study are as follows:

Aim 1. Impact of HCV Cure on CNS Outcomes. Determine how curing HCV without IFN alters CNS outcomes in substance users with chronic HCV disease.

Aim 2. Correlates of CNS Outcomes. Determine the viral and host correlates of Aim 1's neurocognitive outcomes.

Aim 3. Impact of HIV Co-infection. Explore how HIV alters the relationships observed in Aims 1 and 2. Hypothesis 3: Compared with HCV mono-infected adults, SVR will be less likely to result in improved CNS outcomes in HCV/HIV co-infected adults.

Conditions

Hepatitis C; Human Immunodeficiency Virus

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Adults (18 years old or older) with chronic HCV and NCI with a GDS greater than or equal to 0.35 (n=40).

2. Presence of chronic HCV infection based on chart review will be defined as positive for anti-HCV antibody or HCV RNA at least 6 months before screening.

3. Plan to receive HCV treatment from their primary care physician within 1 month of enrollment.

4. For the HIV/HCV co-infected group only, subjects must have HIV. HIV status will be obtained through self-report. Self-report will be confirmed at the pretreatment visit using a HIV-1 point of care test. In the event that point of care test and self-report are discordant, then HIV status will be confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV-1 and/or E/CIA, or by HIV-1 antigen, or plasma HIV-1 RNA viral load.

Exclusion Criteria

1. Cirrhosis or bridging fibrosis (mHAI stages 4-6 or its equivalent).

• Liver biopsy at any time showing mHAI stage 4 or higher fibrosis OR
• FibroScan within 12 months demonstrating liver stiffness of ≥9.5 kPa OR
• APRI ≥2.0 and FIB-4 ≥3.25
• NOTE: If APRI and FIB-4 are discordant one of the other forms of fibrosis staging must be used.

2. Any cause of liver disease other than chronic HCV infection, including but not limited to the following:

• Hemochromatosis
• Alpha-1 antitrypsin deficiency
• Wilson's disease
• Autoimmune hepatitis
• Alcoholic liver disease
• Drug-related liver disease

3. Severe NC confounding conditions (stroke, head injury, or developmental learning disability).

4. Regular use of anti-inflammatory drugs.

5. Current or recent treatment with pegylated interferon (PEG-IFN).

6. Other active inflammatory process (major infection, malignancy, rheumatoid arthritis/autoimmune disorder) within the prior 28 days.

7. Uncontrolled or active depression or other psychiatric disorder that in the opinion of the site investigator might preclude adherence to study requirements or impact NC functioning and assessments.

8. Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.

9. Presence of active or acute AIDS-defining opportunistic infections within 12 weeks prior to study entry.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of California, San Diego

OTHER

Sponsor Role: lead

Responsible Party

Ajay Bharti

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ajay Bharti, M.D.

Role: PRINCIPAL_INVESTIGATOR

UCSD

Locations

Ucsd Hnrp

San Diego, California, United States

Countries

United States

Other Identifiers

CO-US-337-1786

Identifier Type: -

Identifier Source: org_study_id