Reconsolidation and EMDR

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2017-05-07

Brief Summary

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Blocking of reconsolidation by pharmacological or behavioral means offers the therapeutic possibility of weakening traumatic memories in posttraumatic stress disorder (PTSD). Two reconsolidation-based interventions, propranolol and extinction learning, have been shown to weaken fear memories in human healthy subjects. However, the success of these interventions seems to be limited to weak conditioned fear memories. This calls for new, potentially more efficacious, interventions to be tested. Bilateral eye movements seem to be a promising candidate intervention for blocking reconsolidation due to the compelling evidence of Eye Movement Desensitization and Reprocessing as effective treatment in PTSD. The investigators' aim is to test bilateral eye movements as an active reconsolidation-blocking intervention in an optimized differential fear conditioning procedure that the investigators have recently developed. This novel experimental assay creates stronger fear memories in healthy individuals.

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Detailed Description

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Conditions

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PTSD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Delayed Bilateral Eye Movements

Delayed Bilateral Eye Movements after reactivation of fear-memory.

Group Type EXPERIMENTAL

Delayed Bilateral Eye Movements

Intervention Type BEHAVIORAL

Bilateral Eye Movements followed by a 10 min delay after reactivation of fear-memory.

Undelayed Bilateral Eye Movements

Undelayed Bilateral Eye Movements after reactivation of fear-memory.

Group Type ACTIVE_COMPARATOR

Undelayed Bilateral Eye Movement

Intervention Type BEHAVIORAL

Bilateral Eye Movements followed by no delay after reactivation of fear-memory. reactivation of the fear memory trace during which the reactivated memory is assumed to be in a labile state.

Interventions

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Delayed Bilateral Eye Movements

Bilateral Eye Movements followed by a 10 min delay after reactivation of fear-memory.

Intervention Type BEHAVIORAL

Undelayed Bilateral Eye Movement

Bilateral Eye Movements followed by no delay after reactivation of fear-memory. reactivation of the fear memory trace during which the reactivated memory is assumed to be in a labile state.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male or female between 18 years and 60 years of age
* Presence of a manageable, nonphobic fear of spiders as determined by scores above the mean (male: 8.06; female: 10.46) on the German adapted Spider Phobia Questionnaire (SPQ; 38) and phobia criteria extracted from the Structured Clinical Interview for DSM-5 Axis I Disorders (SCID-I; 39)
* Signed Informed Consent after being informed

Exclusion Criteria

* Current or past neurological or other medical condition affecting the brain
* Current use of any medication (except contraceptives, herbal medicine)
* Known or suspected non-compliance, drug or alcohol misuse
* Presence of any current psychiatric disorders determined by the Mini International Neuropsychiatric Interview (MINI; 40)
* Inability to follow the procedures of the study, e.g. due to language problems
* No SC response to physical (Valsalva maneuver), psychological (mental arithmetic) and/or auditive (handclapping) stressor

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes