MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers
NCT ID: NCT02570581
Last Updated: 2015-10-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE1
16 participants
INTERVENTIONAL
2014-06-30
2014-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Usefulness of Metoclopramide to Improve Endoscopic Visualization in Upper Gastrointestinal Bleeding
NCT06297954
Efficacy of Three Antiemetics in Preventing Nausea and Vomiting
NCT05533281
Motion Sickness on Astrolabe's Vessel
NCT02911402
Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis
NCT02357420
A Randomized, Open-label, Two-way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis
NCT00139893
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Main objective. To identify from the advice of healthy volunteers, on the gustative aspect, which medicine it is acceptable or not recommended to add once crushed or opened in food.
Secondary objective. To search for alternative solutions. Type of study. Phase I study on healthy volunteers. It is a cohort study, with a hedonic, descriptive test in a single group and a single one session, to test the taste of 10 drugs crushed in some jelly and apple compote.
Volunteers participating in the study will be 16 healthy volunteers: 8 professionals of the restaurant, the catering, the food aromas, the nutrition and the dietetics, and 8 doctors, pharmacists, dental surgeons, nurses and/or nurse's aides.
Inclusion criteria: healthy volunteers over 18 years, without allergy known about 10 drugs to be tested. Pregnant women will not be included.
Criteria of evaluation:
1. Quantitative: mark from 0 (bad taste) to 10 (no taste or no unpleasant taste) for the jelly and compote specimens mixed with crushed drugs.
2. Qualitative: description of the perceived aroma (acid, bitter, sweet, salty, astringent, pricking, aromatic).
Brief description of the methodology:
The investigator shall test 10 drugs the most prescribed in the Korian group nursing homes, identified as being able to be crushed or opened. The assay will take place during a single one-morning session in a room specifically dedicated to clinical assays and with the help of a nursing staff trained for clinical assays (Nice University Hospital). Medicine will be crushed in parallel in some jelly and apple compote: 10 single drugs, 1 mixture of 6 drugs and 1 comparator (unmodified plain jelly and compote). Every volunteer will make these 24 tests blind and will fill a scoring sheet. He or she will spit out and have an oral rinse with some water between two tests; the dose susceptible to be ingested will be about 1/500th of a unit dosage. Excepted a risk of allergy, the medical risk is thus unimportant for the tasters. Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Individual duration of the study. One morning. Total duration of the study. One year and half, for the organization of the test and the publication of the results.
Expected fallout
* The fight against senile anorexia and malnutrition, in elderly people who are given polypharmacy, by improving care protocols.
* Proposal of alternative solutions such as pediatric or galenic forms if they exist, other food substrates or new additives which would allow to mask the taste of certain drugs crushed in food.
* Incitement in a policy of reduction of drugs for the elderly.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
SINGLE_GROUP
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Plain jelly control
Plain jelly control
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Jelly with: Paracetamol
Jelly with:
Paracetamol
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Jelly with Furosemide
Jelly with Furosemide
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Jelly with memantine
Jelly with memantine
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with zopiclone
Jelly with zopiclone
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with alprazolam
elly with alprazolam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with Oxazepam
Jelly with Oxazepam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with donepezil
jelly with donepezil
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Jelly with clopidogrel
jelly with clopidogrel
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with ramipril
jelly with ramipril
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Plain apple compote control
Plain apple compote control
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Apple compote Paracetamol
Apple compote Paracetamol
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Furosemide
Apple compote Furosemide
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Memantine
Apple compote Memantine
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Zopiclone
Apple compote Zopiclone
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Alprazolam
Apple compote Alprazolam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Oxazepam
Apple compote Oxazepam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Donepezil
Apple compote Donepezil
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Clopidogrel
Apple compote Clopidogrel
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple compote Ramipril
Apple compote Ramipril
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Plain apple compote control
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Jelly with:Paracetamol
A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content.
The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests.
The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet.
Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.
Jelly with Furosemide
Jelly with Levothyroxine sodium salt
Jelly with Memantine
Jelly with Zopiclone
Jelly with Alprazolam
Jelly with Oxazepam
Jelly with Donepezil
Jelly with Clopidogrel
Jelly with Ramipril
Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain jelly control
Apple compote Paracetamol
Apple compote Furosemide
Apple compote Levothyroxine sodium salt
Apple compote Memantine
Apple compote Zopiclone
Apple compote Alprazolam
Apple compote Oxazepam
Apple compote Donepezil
Apple compote Clopidogrel
Apple compote Ramipril
Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
18 Years
70 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Centre Hospitalier Universitaire de Nice
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Center for Clinical Research - Archet 1 Hospital Nice Hospital
Nice, , France
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2013-003461-34
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.