Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
NCT ID: NCT03560583
Last Updated: 2025-02-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2021-05-05
2028-07-31
Brief Summary
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Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum.
The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Metoclopramide 10 mg BID
Metoclopramide
Metoclopramide 10 mg BID
Placebo 10 mg BID
Placebo Oral Tablet
Placebo 10 mg BID
Interventions
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Metoclopramide
Metoclopramide 10 mg BID
Placebo Oral Tablet
Placebo 10 mg BID
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Prolactinemia
* Women treated with dopamine agonists
18 Years
54 Years
FEMALE
Yes
Sponsors
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Barzilai Medical Center
OTHER
Responsible Party
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Leon Grin
Gynecological Doctor
Principal Investigators
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Leon Grin, MD
Role: PRINCIPAL_INVESTIGATOR
Barzilai Medical Center
Locations
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Barzilai University Medical Center
Ashkelon, Ashkelon District, Israel
Countries
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Central Contacts
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Facility Contacts
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References
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Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V. Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2018 Sep;31(18):2492-2505. doi: 10.1080/14767058.2017.1342805. Epub 2017 Jul 11.
Hernandez I, Parra A, Mendez I, Cabrera V, Cravioto MC, Mercado M, Diaz-Sanchez V, Larrea F. Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome. Arch Med Res. 2000 Mar-Apr;31(2):216-22. doi: 10.1016/s0188-4409(00)00059-x.
Prelevic GM, Wurzburger MI, Peric LA. Metoclopramide effect on serum prolactin LH and FSH in patients with polycystic ovary syndrome. J Endocrinol Invest. 1988 Apr;11(4):255-9. doi: 10.1007/BF03350148.
Mendes MC, Ferriani RA, Sala MM, Moura MD, Carrara HH, de Sa MF. Effect of transitory hyperprolactinemia on in vitro fertilization of human oocytes. J Reprod Med. 2001 May;46(5):444-50.
Other Identifiers
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BRZ 0046-17 CTIL
Identifier Type: -
Identifier Source: org_study_id
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