Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

NCT ID: NCT02570230

Last Updated: 2021-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-01

Study Completion Date

2018-12-31

Brief Summary

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Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Detailed Description

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Conditions

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Pain Postoperative Period

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Control

NSS infusion

Group Type PLACEBO_COMPARATOR

NSS

Intervention Type OTHER

NSS infusion

Ketamine

Ketamine 0.2 mg/kg/hr intravenous infusion

Group Type EXPERIMENTAL

Ketamine

Intervention Type DRUG

Ketamine 0.2 mg/kg/hr intravenous infusion

Interventions

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NSS

NSS infusion

Intervention Type OTHER

Ketamine

Ketamine 0.2 mg/kg/hr intravenous infusion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* ASA physical status 1-3
* elective thoracotomy
* can operate patient-controlled analgesia (PCA) machine

Exclusion Criteria

patient with history of

* allergy to morphine or ketamine
* contraindicate to ketamine
* remain intubated in the postoperative period
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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Sirilak Suksompong

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sirilak Suksompong, MD

Role: PRINCIPAL_INVESTIGATOR

Mahidol University

Locations

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Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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SI2558

Identifier Type: -

Identifier Source: org_study_id

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