Demodex Density, Immune Response and Oxidative Stress in Rosacea Patients
NCT ID: NCT02556827
Last Updated: 2015-09-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
80 participants
OBSERVATIONAL
2015-07-31
2015-12-31
Brief Summary
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Detailed Description
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The aim of our study was to evaluate the status of oxidative stress, matrix metalloproteinase (MMP) and inflammatory markers in systemic circulation, their relationship with demodex density and investigate the role of photoaging and sebum secretion in rosacea.
Forty patients with rosacea and age, gender and skin phenotype matched 40 healthy volunteers were enrolled in the study. Reflectance confocal microscopy (RCM) was used to calculate facial demodex density. The number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM.
Photoaging severity and facial sebum levels were also assessed. Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1 (PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9 (MMP-9) levels in venous blood were measured.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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H, Rosacea patients
Rosacea patients who were between the ages of 18-70, having no systemic illness and who were not smoking.
Obtaining a blood sample; TOC, TAC, OSI, PON-1, ARES, MPO, TNF-α, IL-1β, MMP-1 and MMP-9 levels in venous blood were measured Reflectance confocal microscopy; 1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM. Sebum rate at forehead and right cheek were evaluated with sebumeter. Dermoscopic photoaging scale were assessed by using video dermoscopy.
Obtaining a blood sample
Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1 (PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9 (MMP-9) levels in venous blood were measured.
Reflectance confocal microscopy
1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM.
Sebumeter
Sebum rate at forehead and right cheek were evaluated with sebumeter
Video dermoscopy
Dermoscopic photoaging scale were assessed by using video dermoscopy.
K, Healthy volunteers
Healthy volunteers who were compatible in terms of age, sex and skin phenotype, having no systemic illness and who were not smoking.
Obtaining a blood sample; TOC, TAC, OSI, PON-1, ARES, MPO, TNF-α, IL-1β, MMP-1 and MMP-9 levels in venous blood were measured Reflectance confocal microscopy; 1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM. Sebum rate at forehead and right cheek were evaluated with sebumeter. Dermoscopic photoaging scale were assessed by using video dermoscopy.
Obtaining a blood sample
Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1 (PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9 (MMP-9) levels in venous blood were measured.
Reflectance confocal microscopy
1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM.
Sebumeter
Sebum rate at forehead and right cheek were evaluated with sebumeter
Video dermoscopy
Dermoscopic photoaging scale were assessed by using video dermoscopy.
Interventions
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Obtaining a blood sample
Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1 (PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9 (MMP-9) levels in venous blood were measured.
Reflectance confocal microscopy
1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM.
Sebumeter
Sebum rate at forehead and right cheek were evaluated with sebumeter
Video dermoscopy
Dermoscopic photoaging scale were assessed by using video dermoscopy.
Eligibility Criteria
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Inclusion Criteria
* No systemic illness
* No other inflammatory dermatoses except for rosacea
* No smoking
* Not using any topical, systemic treatment and sunblock at least a month for rosacea or other condition
Exclusion Criteria
* Other inflammatory dermatoses except for rosacea
* Smoking
* Using any topical, systemic treatment and sunblock for rosacea or other condition
* Type 4 rosacea patient (only ocular involvement)
18 Years
70 Years
ALL
Yes
Sponsors
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Bezmialem Vakif University
OTHER
Istanbul Training and Research Hospital
OTHER_GOV
Responsible Party
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Tuğba Falay
Resident Doctor
Principal Investigators
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Tugba Falay
Role: PRINCIPAL_INVESTIGATOR
Istanbul Training and Research Hospital
Vefa Aslı Erdemir
Role: STUDY_DIRECTOR
Istanbul Training and Research Hospital
Mehmet Salih Gürel
Role: STUDY_DIRECTOR
Istanbul Training and Research Hospital
Abdurrahim Kocyigit
Role: STUDY_DIRECTOR
Bezmialem Vakif University
Duygu Erdil
Role: STUDY_CHAIR
Istanbul Training and Research Hospital
Eray Metin Güler
Role: STUDY_CHAIR
Bezmialem Vakif University
Locations
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Istanbul Training and Research Hospital
Istanbul, Org. Abd. Nafiz Gürman, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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71306642-050.01.04
Identifier Type: -
Identifier Source: org_study_id
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