A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Rosacea

NCT ID: NCT02583009

Last Updated: 2016-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

216 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Brief Summary

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This clinical study is to determine the optimum dose of PAC-14028 cream in a therapeutic confirmatory clinical study by evaluating the safety and therapeutic equivalence of PAC-14028 cream 0.1%, 0.3% and 1.0% in patients with rosacea.

Detailed Description

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Conditions

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Rosacea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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PAC-14028 cream 0.1%

PAC-14028 cream 0.1%, Twice daily for 4 weeks

Group Type EXPERIMENTAL

PAC-14028 cream 0.1%

Intervention Type DRUG

Topical application

PAC-14028 cream 0.3%

PAC-14028 cream 0.3%, Twice daily for 4 weeks

Group Type EXPERIMENTAL

PAC-14028 cream 0.3%

Intervention Type DRUG

Topical application

PAC-14028 cream 1.0%

PAC-14028 cream 1.0%, Twice daily for 4 weeks

Group Type EXPERIMENTAL

PAC-14028 cream 1.0%

Intervention Type DRUG

Topical application

PAC-14028 cream vehicle

PAC-14028 cream vehicle, Twice daily for 4 weeks

Group Type PLACEBO_COMPARATOR

PAC-14028 cream vehicle

Intervention Type DRUG

Topical application

Interventions

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PAC-14028 cream 0.1%

Topical application

Intervention Type DRUG

PAC-14028 cream 0.3%

Topical application

Intervention Type DRUG

PAC-14028 cream 1.0%

Topical application

Intervention Type DRUG

PAC-14028 cream vehicle

Topical application

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male and female patients aged 19 - 70 years old
* Among the patients diagnosed with erythematotelangiectatic and papulopustular rosacea in accordance with the diagnostic criteria of the National Rosacea Society Expert Committee
* Subjects with rosacea scored 2 or more according to the Investigator Global Assessment (IGA) at screening

Exclusion Criteria

* Those who can't be diagnosed or assessed for rosacea due to the presence of trauma, tattoo, scar, excessive hairs on the facial region
* Those who have received a facial laser treatment within 6 weeks
* Those who have been administered with oral retinoid or therapeutic vitamin A within 6 months
* Those who have received a hormonal treatment such as estrogen within 3 months
* Those who have been administered with systemic antibiotics or systemic steroid formulation within 4 weeks
* Those who have been administered with local retinoid, local steroid and local antibiotics and local medication for the treatment of rosacea on face within 4 weeks
* Those who have a history of blood disorder that can have a serious effect on the clinical study
* Women who are pregnant, lactating or who plan to be pregnant during the clinical study period or women of childbearing potential who do not use available contraceptive methods
Minimum Eligible Age

19 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Amorepacific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Miyoung Park, PhD

Role: STUDY_DIRECTOR

Amorepacific R&D Center

Locations

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Korea University Ansan Hospital

Ansan-si, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AP-TRPV1_PII-03

Identifier Type: -

Identifier Source: org_study_id

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