Evaluating the Efficacy of the Management of an Online Program of Cognitive Behavioral Therapy for Primary Insomnia

NCT ID: NCT02539862

Last Updated: 2018-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-09

Study Completion Date

2016-05-31

Brief Summary

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The purpose of this study is to evaluate the effectiveness of the management of chronic primary insomnia patients by a computer program guidance of behavioral and cognitive therapies for insomnia (BCT-I).

Detailed Description

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Chronic insomnia is a common sleep disorder (prevalence = 10%) and a risk identified on the physical and mental health. Currently, the treatment involves the prescription of drug treatments by general practitioners, which may be unsuitable for the medium term. It is better to turn to Behavioral and Cognitive Therapies for Insomnia (BCT-I) in the case of primary chronic insomnia. The objective of this study is to evaluate the effectiveness of a computer program guidance BCT-I in patients with chronic primary insomnia. This biomedical research psychotherapeutic assessment will be randomized, controlled versus psychoeducation and conducted in 46 patients with chronic primary insomnia (defined according to Diagnostic and Statistical Manual-5) for which a supported by BCT-I is indicated.

The 46 patients will be randomized into two groups. The subjects in Group 1 will be supported by BCT-I online. And the subjects in group 2 will receive psychoeducation. All patients will be followed by the research team for three months, during which 3 visits (V0 = pre-selection; V1 = visit of randomization and start of the program; V2 = 3 months follow-up visit and end of the study) will be performed in the University Hospital Sleep Disorder Unit of Montpellier. Patients in Group 1 will conduct BCT-I online at home therapy. Patients in group 2 will receive a structured 45-minute session information insomnia (psychoeducation = work performed daily by clinicians in charge of insomnia problems) to the visit 1. All patients in the study will be equipped 2 sensors for the registration of sleep data.

The primary endpoint will be based on the severity of insomnia measured by the ISI after the last online psychotherapy session (3 months) between the 2 groups of patients (BCT-I online and without treatment - psychoeducation ). The analyse efficacity to be conducted by intention to treat.

Conditions

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Chronic Insomnia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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cognitive behavioral therapy online

patients receive cognitive behavioral therapy via an online program

Group Type EXPERIMENTAL

cognitive behavioral therapy online

Intervention Type OTHER

The cognitive behavioral therapy online program is delivered through an accessible web application on a web browser with a personal password

no cognitive behavioral therapy online

patients receive psychoeducation by a doctor

Group Type OTHER

psychoeducation

Intervention Type OTHER

the psychoeducation is delivered by a doctor

Interventions

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cognitive behavioral therapy online

The cognitive behavioral therapy online program is delivered through an accessible web application on a web browser with a personal password

Intervention Type OTHER

psychoeducation

the psychoeducation is delivered by a doctor

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age between 20 and 65
* disorder diagnosis of chronic insomnia (according to Diagnostic and Statistical Manual-5)
* sleep efficiency \<80%
* Index severe insomnia: ISI\> 14/28
* have a computer at home
* Practicing internet regularly in everyday life
* have a personal email address

Exclusion Criteria

* Clinically suffer from insomnia comorbid linked to other sleep disorders
* Presenting an unbalanced psychiatric disorder
* Have Score Beck Depression Inventory (BDI-II) \>29
* Have neurological disorders
* Have severe medical conditions that can affect the quality of sleep
* Have Hypnotic, Anxiolytic, antidepressants Treatment \> 2
* Have antipsychotics, opioids, anticonvulsants, anti-parkinson treatment
* Having a disorder of substance use (alcohol, drugs) in the last 6 months
* Having undertaken a meridian trance journey (± 3H) in the preceding month or during the study period
* Already be treated with CBT-I
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dauvilliers Yves

Role: PRINCIPAL_INVESTIGATOR

Unit of sleep disorders

References

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Leger D, Levy E, Paillard M. The direct costs of insomnia in France. Sleep. 1999 May 1;22 Suppl 2:S394-401.

Reference Type BACKGROUND
PMID: 10394613 (View on PubMed)

Leigh JP. Employee and job attributes as predictors of absenteeism in a national sample of workers: the importance of health and dangerous working conditions. Soc Sci Med. 1991;33(2):127-37. doi: 10.1016/0277-9536(91)90173-a.

Reference Type BACKGROUND
PMID: 1887276 (View on PubMed)

Morin CM, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am J Psychiatry. 1994 Aug;151(8):1172-80. doi: 10.1176/ajp.151.8.1172.

Reference Type BACKGROUND
PMID: 8037252 (View on PubMed)

Murtagh DR, Greenwood KM. Identifying effective psychological treatments for insomnia: a meta-analysis. J Consult Clin Psychol. 1995 Feb;63(1):79-89. doi: 10.1037//0022-006x.63.1.79.

Reference Type BACKGROUND
PMID: 7896994 (View on PubMed)

Gagnon C, Belanger L, Ivers H, Morin CM. Validation of the Insomnia Severity Index in primary care. J Am Board Fam Med. 2013 Nov-Dec;26(6):701-10. doi: 10.3122/jabfm.2013.06.130064.

Reference Type BACKGROUND
PMID: 24204066 (View on PubMed)

Smith MT, Perlis ML, Park A, Smith MS, Pennington J, Giles DE, Buysse DJ. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry. 2002 Jan;159(1):5-11. doi: 10.1176/appi.ajp.159.1.5.

Reference Type BACKGROUND
PMID: 11772681 (View on PubMed)

Irwin MR, Cole JC, Nicassio PM. Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age. Health Psychol. 2006 Jan;25(1):3-14. doi: 10.1037/0278-6133.25.1.3.

Reference Type BACKGROUND
PMID: 16448292 (View on PubMed)

I. Okajima, Y. Komada, and Y. Inoue, A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia. Sleep and Biological Rhythms, 2011. 9(1): p. 24-34.

Reference Type BACKGROUND

Espie CA, Kyle SD, Williams C, Ong JC, Douglas NJ, Hames P, Brown JS. A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application. Sleep. 2012 Jun 1;35(6):769-81. doi: 10.5665/sleep.1872.

Reference Type BACKGROUND
PMID: 22654196 (View on PubMed)

Ritterband LM, Thorndike FP, Gonder-Frederick LA, Magee JC, Bailey ET, Saylor DK, Morin CM. Efficacy of an Internet-based behavioral intervention for adults with insomnia. Arch Gen Psychiatry. 2009 Jul;66(7):692-8. doi: 10.1001/archgenpsychiatry.2009.66.

Reference Type BACKGROUND
PMID: 19581560 (View on PubMed)

Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL. Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004). Sleep. 2006 Nov;29(11):1398-414. doi: 10.1093/sleep/29.11.1398.

Reference Type BACKGROUND
PMID: 17162986 (View on PubMed)

NIH State-of-the-Science Conference Statement on manifestations and management of chronic insomnia in adults. NIH Consens State Sci Statements. 2005 Jun 13-15;22(2):1-30.

Reference Type BACKGROUND
PMID: 17308547 (View on PubMed)

Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008 Oct 15;4(5):487-504.

Reference Type BACKGROUND
PMID: 18853708 (View on PubMed)

Thorndike FP, Ritterband LM, Gonder-Frederick LA, Lord HR, Ingersoll KS, Morin CM. A randomized controlled trial of an internet intervention for adults with insomnia: effects on comorbid psychological and fatigue symptoms. J Clin Psychol. 2013 Oct;69(10):1078-93. doi: 10.1002/jclp.22032. Epub 2013 Aug 28.

Reference Type BACKGROUND
PMID: 24014057 (View on PubMed)

Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001 Jul;2(4):297-307. doi: 10.1016/s1389-9457(00)00065-4.

Reference Type BACKGROUND
PMID: 11438246 (View on PubMed)

Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP. Development of a fatigue scale. J Psychosom Res. 1993;37(2):147-53. doi: 10.1016/0022-3999(93)90081-p.

Reference Type BACKGROUND
PMID: 8463991 (View on PubMed)

Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540.

Reference Type BACKGROUND
PMID: 1798888 (View on PubMed)

Chevalier J, de Pouvourville G. Valuing EQ-5D using time trade-off in France. Eur J Health Econ. 2013 Feb;14(1):57-66. doi: 10.1007/s10198-011-0351-x. Epub 2011 Sep 21.

Reference Type BACKGROUND
PMID: 21935715 (View on PubMed)

Leger D, Morin CM, Uchiyama M, Hakimi Z, Cure S, Walsh JK. Chronic insomnia, quality-of-life, and utility scores: comparison with good sleepers in a cross-sectional international survey. Sleep Med. 2012 Jan;13(1):43-51. doi: 10.1016/j.sleep.2011.03.020. Epub 2011 Nov 16.

Reference Type BACKGROUND
PMID: 22093806 (View on PubMed)

Cartwright RD. Alcohol and NREM parasomnias: evidence versus opinions in the international classification of sleep disorders, 3rd edition. J Clin Sleep Med. 2014 Sep 15;10(9):1039-40. doi: 10.5664/jcsm.4050. No abstract available.

Reference Type BACKGROUND
PMID: 25221449 (View on PubMed)

Other Identifiers

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9454

Identifier Type: -

Identifier Source: org_study_id

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