Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects

NCT ID: NCT02523742

Last Updated: 2020-09-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

152 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Study Completion Date

2015-04-23

Brief Summary

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Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.

Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Detailed Description

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Conditions

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Neuropsychiatric Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Neuropsychiatric Disorders

Neuropsychiatric Disorders patients

Group Type OTHER

IMRf

Intervention Type DEVICE

language task and a reference task (rest and Tamil)

Intervention Type OTHER

Healthy volunteers

control subjects matched to patients by age, sex, socio-cultural level and laterality

Group Type OTHER

IMRf

Intervention Type DEVICE

language task and a reference task (rest and Tamil)

Intervention Type OTHER

Interventions

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IMRf

Intervention Type DEVICE

language task and a reference task (rest and Tamil)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients under 65 years
* Schizophrenics, bipolar or schizoaffective (DSM IV)
* Patients who signed informed consent

Exclusion Criteria

* Women with childbearing potential without effective contraception or positive pregnancy test.
* Contra-indications to fMRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Caen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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05-097

Identifier Type: -

Identifier Source: org_study_id

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