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fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

NCT ID: NCT00478491

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

390 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-01-31

Study Completion Date

2011-07-31

Brief Summary

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The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Detailed Description

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Conditions

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Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Persons with a parent with Alzheimer's disease

No interventions assigned to this group

2

Persons whose parents survived to old age without memory problems

No interventions assigned to this group

3

Persons with diagnosed mild cognitive impairment

No interventions assigned to this group

4

Persons without memory problems

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* MCI Group: Diagnosis of mild cognitive impairment
* AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
* Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria

* Claustrophobia
* Metallic or electronic implants or devices that are not MRI-safe
Minimum Eligible Age

40 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sterling C Johnson, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin/VA GRECC

Locations

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University of Wisconsin - Wisconsin Comprehensive Memory Program

Madison, Wisconsin, United States

Site Status

Countries

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United States

References

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Ries ML, Jabbar BM, Schmitz TW, Trivedi MA, Gleason CE, Carlsson CM, Rowley HA, Asthana S, Johnson SC. Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal. J Int Neuropsychol Soc. 2007 May;13(3):450-61. doi: 10.1017/S1355617707070488.

Reference Type RESULT
PMID: 17445294 (View on PubMed)

Johnson SC, Schmitz TW, Trivedi MA, Ries ML, Torgerson BM, Carlsson CM, Asthana S, Hermann BP, Sager MA. The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation. J Neurosci. 2006 May 31;26(22):6069-76. doi: 10.1523/JNEUROSCI.0959-06.2006.

Reference Type RESULT
PMID: 16738250 (View on PubMed)

Trivedi MA, Schmitz TW, Ries ML, Torgerson BM, Sager MA, Hermann BP, Asthana S, Johnson SC. Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC Med. 2006 Jan 13;4:1. doi: 10.1186/1741-7015-4-1.

Reference Type RESULT
PMID: 16412236 (View on PubMed)

Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol. 2005 Dec 2;5:23. doi: 10.1186/1471-2377-5-23.

Reference Type RESULT
PMID: 16321166 (View on PubMed)

Ries ML, Schmitz TW, Kawahara TN, Torgerson BM, Trivedi MA, Johnson SC. Task-dependent posterior cingulate activation in mild cognitive impairment. Neuroimage. 2006 Jan 15;29(2):485-92. doi: 10.1016/j.neuroimage.2005.07.030. Epub 2005 Aug 15.

Reference Type RESULT
PMID: 16102979 (View on PubMed)

Related Links

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http://www.brainmap.wisc.edu

Website for the Sterling Johnson Imaging Lab

Other Identifiers

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NIH RO1 AG021155A

Identifier Type: -

Identifier Source: secondary_id

2002-515

Identifier Type: -

Identifier Source: org_study_id