Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-05-31

Study Completion Date

2014-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes. This experiment now will complete the data set-up obtained during the MARS500 study on how these respective individuals will re-act to highly physically and emotionally challenging situations during a parabolic flight.

This add-on experiment to MARS500 will enable answering to the following questions i) if the stress response systems - when compared for two conditions but in the same individuals - do react uniformly and ii) if those subjects prone to have adequate stress response pattern will show gradually less immune modulation effects.

The understanding of the complex interactions of stress and immunity under chronic and acute stress conditions might help to enable adequate health and immune monitoring and might as well suggest suitable countermeasures for the prevention of the unwanted immunological effects during long-term confinement and space missions.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels

NCT06387940

Healthy

COMPLETED NA

A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases

NCT03193177

Fasting Chronic Disease Autoimmune Diseases +6 more

COMPLETED

The Fasting II Study

NCT01792986

Diabetes Metabolic Diseases

COMPLETED NA

Effects of Daily Eating Duration on Health

NCT05964179

Body Weight Maintenance Nutritional and Metabolic Diseases

COMPLETED NA

Effects of Periodic Fasting Versus Daily Energy Restriction on Metabolic Health

NCT01769976

Insulin Resistance

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Stress response measurements

Group Type OTHER

Parabolic flight

Intervention Type OTHER

neuro-endocrine measurements

Intervention Type OTHER

psychic stress tests, stress hormones: prolactin, cortisol, endo-cannabinoids

immunological measurements

Intervention Type OTHER

blood cell counts, B2 integrins, cytokines, C-reactive protein

cellular energy metabolism measurements

Intervention Type OTHER

purines, lactate

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Parabolic flight

Intervention Type OTHER

neuro-endocrine measurements

psychic stress tests, stress hormones: prolactin, cortisol, endo-cannabinoids

Intervention Type OTHER

immunological measurements

blood cell counts, B2 integrins, cytokines, C-reactive protein

Intervention Type OTHER

cellular energy metabolism measurements

purines, lactate

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy volunteers (men or women)
* Aged from 18 to 65
* Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC)
* Who accepted to take part in the study
* Who have given their written stated consent
* Who participated in the MARS500 experiment
* Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection.