Effects of Periodic Fasting Versus Daily Energy Restriction on Metabolic Health
NCT ID: NCT01769976
Last Updated: 2015-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
88 participants
INTERVENTIONAL
2013-01-31
2015-09-30
Brief Summary
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It is hypothesized that periodic fasting, with or without weight loss, will be as effective as daily energy restriction to improve markers of metabolic health and energy metabolism.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Daily energy restriction
25% reduction in daily energy intake
Energy restriction
Energy balance diet
Diet provides 100% of energy requirements and is designed to achieve weight stability
Energy balance diet
Periodic fasting with weight loss
Fast 3 days per week, and consume 1.5 times usual amount of food on other days
Periodic fasting
Energy restriction
Periodic fasting without weight loss
Fast 3 days per week, and consume double usual amount of food on other days
Periodic fasting
Energy balance diet
Interventions
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Periodic fasting
Energy restriction
Energy balance diet
Eligibility Criteria
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Inclusion Criteria
* weight stable (\<5% fluctuation in body weight for the 6 months prior to study entry)
Exclusion Criteria
* use of prescribed or non-prescribed medications with may affect energy metabolism, gastrointestinal function, body weight, or appetite
* recent weight changes in 3 months prior to study entry
* uncontrolled asthma, current fever, upper respiratory infections
* individuals who regularly perform high intensity exercise (\>2 sessions per week)
* pregnancy, lactation (breast feeding), women who are planning to become pregnant
* current intake of \>140g of alcohol per week
* current smoker of cigarettes/cigars/marijuana
* current intake of any illicit substance
* experience claustrophobia in confined spaces
* has donated blood within the past 3 months
* unable to comprehend the study protocol
* experiences migraines
35 Years
70 Years
FEMALE
Yes
Sponsors
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University of Adelaide
OTHER
Responsible Party
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A/Prof Leonie Heilbronn
Associate Professor
Principal Investigators
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Leonie Heilbronn
Role: PRINCIPAL_INVESTIGATOR
University of Adelaide
Locations
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Royal Adelaide Hospital
Adelaide, South Australia, Australia
Countries
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References
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Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi AM, Tsilidis K, Dehghan A. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. doi: 10.1002/14651858.CD013496.pub2.
Hutchison AT, Liu B, Wood RE, Vincent AD, Thompson CH, O'Callaghan NJ, Wittert GA, Heilbronn LK. Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight. Obesity (Silver Spring). 2019 Jan;27(1):50-58. doi: 10.1002/oby.22345.
Chen M, Liu B, Wilkinson D, Hutchison AT, Thompson CH, Wittert GA, Heilbronn LK. Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance. Obes Res Clin Pract. 2017 Mar-Apr;11(2):227-232. doi: 10.1016/j.orcp.2016.07.004. Epub 2016 Aug 11.
Other Identifiers
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APP1023401
Identifier Type: -
Identifier Source: org_study_id