Study Results
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View full resultsBasic Information
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COMPLETED
1906 participants
OBSERVATIONAL
2009-01-31
2019-03-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Siklos
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* With symptomatic sickle cell syndrome
* Treated with Siklos®
* Having been informed of the study by the initiating physician and consenting to participate to the cohort.
2 Years
ALL
No
Sponsors
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Theravia
INDUSTRY
Responsible Party
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Principal Investigators
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Frédéric Galacteros, MD
Role: PRINCIPAL_INVESTIGATOR
Hôpital henri Mondor (Adults)
Mariane de Montalembert, MD
Role: PRINCIPAL_INVESTIGATOR
Hôpital Necker Enfants Malades (Children)
Locations
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CHU d'Amiens - Picardie - Site sud
Amiens, , France
Centre Hospitalier Robert Ballanger, pédiatrie et néonatalogie
Aulnay-sous-Bois, , France
Hôpital Avicenne; médecine interne
Bobigny, , France
Hôpital Jean Verdier; médecine interne
Bondy, , France
Hôpital Jean Verdier; pédiatrie
Bondy, , France
CHU Bordeaux, urgences pédiatriques
Bordeaux, , France
Hôpital Saint-André
Bordeaux, , France
CHU Estaing, pédiatrie
Clermont-Ferrand, , France
Hôpital Louis Mourier; pédiatrie
Colombes, , France
Hôpital Louis Mourier; service de pédiatrie
Colombes, , France
Centre hospitalier intercommunal de Créteil
Créteil, , France
Hôpital Henri Mondor, centre de la Drépanocytose
Créteil, , France
Centre Hospitalier de Gonesse, médecine interne
Gonesse, , France
Centre Hospitalier de Gonesse, pédiatrie
Gonesse, , France
CHU de Grenoble, hôpital Couple Enfant
Grenoble, , France
CHU de Grenoble
Grenoble, , France
CHU de Limoges
Limoges, , France
Hôpital Mère-Enfant
Limoges, , France
Hôpital Edouard Herriot, hémovigilance
Lyon, , France
Institut d'Hématologie et d'Oncologie Pédiatrique
Lyon, , France
CHU Timone
Marseille, , France
Hôpital de la Conception, médecine interne
Marseille, , France
Centre Hospitalier Intercommunal André Grégoire
Montreuil, , France
CHU Nantes, Hôpital Hôtel Dieu
Nantes, , France
Hôpital Trousseau; pédiatrie générale
Paris, , France
Hôpital Européen Georges Pompidou
Paris, , France
Hôpital Necker enfants, maladies infectieuses et tropicales
Paris, , France
Hôpital Necker; biothérapie
Paris, , France
Hôpital Necker; maladies infectieuses et tropicales
Paris, , France
Hôpital Robert Debré, immunologie-hématologie pédiatrique
Paris, , France
CHR Reims, American Memorial Hospital
Reims, , France
CHU Rennes, Hôpital Pontchaillou
Rennes, , France
CHU Rennes, hôpital Sud
Rennes, , France
CHU Charles Nicolle
Rouen, , France
CHU de Rouen - Hôpital Charles Nicolle
Rouen, , France
Centre Hospitalier Delafontaine, médecine interne
Saint-Denis, , France
Centre Hospitalier Delafontaine, pédiatrie
Saint-Denis, , France
CHRU Strasbourg, Hôpital de Hautepierre
Strasbourg, , France
CHU Toulouse; hôpital des enfants
Toulouse, , France
Institut Universitaire du cancer; médecine interne
Toulouse, , France
CHU Nancy, Brabois enfants
Vandœuvre-lès-Nancy, , France
CH André Rosemon
Cayenne, , French Guiana
CMCK
Kourou, , French Guiana
CH Ouest Guyanais
Saint-Laurent-du-Maroni, , French Guiana
Charité-Universitätsmedizin, Berlin
Berlin, , Germany
Pädiatrie Klinikum Delmenhorst
Delmenhorst, , Germany
Heinrich-Heine Universität Düsseldorf
Düsseldorf, , Germany
University of Freiburg
Freiburg im Breisgau, , Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, , Germany
München
München, , Germany
Laiko General Hospital
Athens, , Greece
CH Basse-Terre, adultes
Basse-Terre, , Guadeloupe
CH Basse-Terre, enfants
Basse-Terre, , Guadeloupe
CHU Pointe à Pitre
Pointe-à-Pitre, , Guadeloupe
Clinica Pediatrica AOU
Napoli, , Italy
Azienda Ospedaliera-University of Padova
Padua, , Italy
Azienda Ospedaliera Universitaria Integrata (AOUI Verona)
Verona, , Italy
CHU Fort de France
Fort-de-France, , Martinique
Hôpital Pierre Zobda-Quitman
Fort-de-France, , Martinique
CH Lamentin
Le Lamentin, , Martinique
Countries
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References
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Allali S, Galacteros F, Oevermann L, Cannas G, Joseph L, Loko G, Elenga N, Benkerrou M, Etienne-Julan M, Castex MP, Brousse V, de Montalembert M. Hydroxyurea is associated with later onset of acute splenic sequestration crisis in sickle cell disease: Lessons from the European Sickle Cell Disease Cohort-Hydroxyurea (ESCORT-HU) study. Am J Hematol. 2024 Apr;99(4):555-561. doi: 10.1002/ajh.27214. Epub 2024 Jan 22.
de Montalembert M, Voskaridou E, Oevermann L, Cannas G, Habibi A, Loko G, Joseph L, Colombatti R, Bartolucci P, Brousse V, Galacteros F; All ESCORT HU Investigators. Real-Life experience with hydroxyurea in patients with sickle cell disease: Results from the prospective ESCORT-HU cohort study. Am J Hematol. 2021 Oct 1;96(10):1223-1231. doi: 10.1002/ajh.26286. Epub 2021 Jul 23.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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ESCORT-HU
Identifier Type: -
Identifier Source: org_study_id
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