Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.

NCT ID: NCT02486419

Last Updated: 2016-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

95 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2016-08-31

Brief Summary

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The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans.

Human adipose tissue biopsies are taken from patients admitted for elective surgery in the neck. During the surgical procedure a subcutaneous adipose tissue biopsy is taken for reference.

Detailed Description

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The knowledge of brown adipose tissue (BAT) is derived mainly from studies in rodents where cold is an important regulator of BAT development and function. Yet, little is known about the regulation of BAT in humans.

With this study the investigators aim to investigate the effects of seasonal changes in outdoor temperature on genetic markers of BAT in human deep neck adipose tissue.

Project participants are patients who are admitted to Aarhus University Hospital for elective neck surgery. Operations are primarily due to suspected malignancy in the thyroid gland or hyperparathyroidism.No additional surgery is necessary to obtain the biopsies.

Conditions

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Nonshivering Thermogenisis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Summer

Outdoor weather

Intervention Type OTHER

Seasonal changes in temperature

Winter

Outdoor weather

Intervention Type OTHER

Seasonal changes in temperature

Interventions

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Outdoor weather

Seasonal changes in temperature

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* written concent

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Peter Breining

MD PhD student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bjørn Richelsen, MD, PhD

Role: STUDY_DIRECTOR

Aarhus University Hospital

Locations

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Aarhus University Hospital

Aarhus, Central Jutland, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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1-10-72-297-14

Identifier Type: -

Identifier Source: org_study_id

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