Effects of Plasmapheresis on Aging Biomarkers

NCT ID: NCT05004220

Last Updated: 2023-09-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-06

Study Completion Date

2023-02-10

Brief Summary

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The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.

Detailed Description

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Conditions

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Aging Plasmapheresis

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

Group 1 consists of first time donors undergoing all 8 tracked plasmaphereses.

Plasmapheresis

Intervention Type PROCEDURE

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.

Group 2

Group 2 consists of first time donors undergoing only last 4 plasmaphereses, serving as control for the first 4 donations.

Plasmapheresis

Intervention Type PROCEDURE

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.

Interventions

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Plasmapheresis

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Generally healthy volunteer subjects age 40 - 60
2. 50:50 man and woman

Exclusion Criteria

1. Subjects excluded from plasma donation protocols (serious illness, infection, etc)
2. Subjects undergoing stronger anti-aging interventions
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital Hradec Kralove

OTHER

Sponsor Role collaborator

Longevitytech.fund a.s.

UNKNOWN

Sponsor Role collaborator

Clock Foundation

UNKNOWN

Sponsor Role collaborator

AGECURVE LIMITED

UNKNOWN

Sponsor Role collaborator

Charles University, Czech Republic

OTHER

Sponsor Role lead

Responsible Party

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Pavel Borsky

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Charles University, Medical Faculty in Hradec Kralove

Hradec Králové, , Czechia

Site Status

Countries

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Czechia

Other Identifiers

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202103 P07

Identifier Type: -

Identifier Source: org_study_id

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