Polymorphisms in Key Genes of Glycolytic Pathway: Influence on Radiosensitivity in Nasopharyngeal Carcinoma

NCT ID: NCT02481089

Last Updated: 2016-02-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Brief Summary

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Warburg effect is an important feature of tumors,and genetic variation is one of the main factors of individual differences to radiotherapy treatment response for nasopharyngeal carcinoma(NPC). Through the previous work investigators found that the p53 codon72 (Pro/Arg) was related to the prognosis of NPC; Using the method of proteomics, investigators discovered glycolysis related gene such as PGK1, ALDOA,was associated with radiosensitivity.Thus,with all the previous work,investigators hypothesize that the key gene polymorphisms in glycolytic pathway, such as p53 , influence the glycolytic pathway,which leads to differences in radiosensitivity of NPC. This projects will include 600 cases of patients with NPC to detect common glycolytic key genes polymorphisms. Besides,investigators correlate these factors with their radiosensitivity and prognosis.Then, prediction model will be established, and validation of the prediction model will be done. Using enzyme-labeling instrument ,comet assay and clonogenic assay,cytological experiments will further investigate the influence of key gene polymorphisms on the glycolysis efficiency and mechanism of radiation sensitivity.Thus,investigators could provide theoretical basis of individualized treatment for NPC.

Detailed Description

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Conditions

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Nasopharyngeal Carcinoma Single Nucleotide Polymorphisms Radiosensitivity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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training group

validation group

Intervention Type OTHER

Interventions

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validation group

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* pathological identified NPC
* KPS≥70
* tolerable and agree for IMRT and concurrent chemotherapy
* without severe other diseases
* informed consent

Exclusion Criteria

* reject treatment
* cannot tolerate the treatment
* distant metastasis before treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hunan Province Tumor Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hui Wang

chief of thoracic radiation oncology department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hunan province tumor pospital

Changsha, Hunan, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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shengqi wu, M.D.

Role: primary

13807316075

Other Identifiers

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warburg snp

Identifier Type: -

Identifier Source: org_study_id

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