Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2013-12-31

Brief Summary

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The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

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Detailed Description

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Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Conditions

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Kidney Transplantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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SVV and PPV

SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences)

PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System)

Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Group Type EXPERIMENTAL

Fluid loading

Intervention Type PROCEDURE

fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients

Interventions

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Fluid loading

fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients

Intervention Type PROCEDURE

Other Intervention Names

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HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Eligibility Criteria

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Inclusion Criteria

\- chronic renal failure patients undergoing renal transplantation

Exclusion Criteria

* patients with cardiac arrhythmia
* patients with reduced left ventricular function (EF \< 40%)
* patients with valvular heart disease
* patients intracardiac shunt
* patients with pulmonary hypertension
* patients with extensive peripheral vascular disease
* patients with preoperative use of vasopressors or inotropics

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No