Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

186 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2019-01-21

Brief Summary

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Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.

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Detailed Description

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Conditions

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Hip Fracture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Group D

General anesthesia with desflurane

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

Inhalation anesthesia with desflurane at age-adjusted MAC of 0.8\~1.0

Group P

General anesthesia with propofol total intravenous anesthesia

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

Total intravenous anesthesia with propofol target controlled infusion

Group S

Spinal anesthesia with 0.5% bupivacaine

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

Spinal anesthesia with 0.5% bupivacaine

Interventions

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Desflurane

Inhalation anesthesia with desflurane at age-adjusted MAC of 0.8\~1.0

Intervention Type DRUG

Propofol

Total intravenous anesthesia with propofol target controlled infusion

Intervention Type DRUG

Bupivacaine

Spinal anesthesia with 0.5% bupivacaine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1\. Patients older than 65 years scheduled for elective or emergency hip fracture surgery.

Exclusion Criteria

1. Patient refusal
2. Inflammation or wound at puncture site, increased intracranial pressure, bleeding diathesis
3. Allergies to propofol or its ingredients, soybeans or peanuts
4. Patients with altered mental status
5. Illiterate patients or foreigners

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No