Co-operative Behavior and Decision-making in Frontal Lobe Epilepsy

NCT ID: NCT02441478

Last Updated: 2025-09-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-02-28
• Study Completion Date: 2015-09-30

Brief Summary

Epilepsy is a frequent neurological disorder with about a third of patients having seizures despite treatment. At least some of these seizures can be linked to a low compliance and therapy adherence of patients. Compliance is defined as "the extent to which a person's behavior (in terms of taking medication, following diets, or executing life style changes) coincides with medical or health advice". Therapy adherence of patients suffering from epilepsy is low with reported rates between 30 and 50%, although adherence to anticonvulsive drug therapy is critical for effective disease management and low therapy adherence is associated to higher mortality in epilepsy. The reasons for low therapy adherence are still a matter of research. Some known factors influencing compliance in epilepsy are related to its chronic nature, but others seem to lie in a complex interaction between psychiatric comorbidity and an impairment of neural systems underlying behavior. Furthermore, therapy adherence rests a variable difficult to measure, especially in epileptic patients where classical tools such as questionnaires and electronic monitoring devices have been shown to be imprecise. It has been argued that the term 'compliance' should be replaced by 'co-operative behavior' and non-compliance can therefore be interpreted as troubled co-operative behavior. This behavioral approach offers the potential of using tools and methods of the latest developments in behavioral neuroscience. Neuroeconomics, a scientific field on the border of psychology, economics and neuroscience, has used economic game paradigms in order to operationalize cooperative behavior and to identify several brain areas by functional brain imaging that have been linked to social co-operative behavior. The majority of these brain areas are located in the frontal cortex [ventromedial frontal/orbitofrontal cortex, and rostral anterior cingulate cortex. Epilepsies originating in the frontal lobe are subsumed under the term "frontal lobe epilepsy" (FLE) and represent 20-30% of all partial seizures and 25% of all refractory focal epilepsies referred to epilepsy surgery.

The investigator's project plans to study compliance and cooperative behavior of patients suffering from frontal lobe epilepsies through a neuroeconomic approach by (1) comparing the behavior of these patients in the prisoners' dilemma game to the behavior of age-, gender-, and education-matched healthy controls, (2) correlation of game behavior to brain activation measured by functional magnetic resonance imaging in both patients and healthy controls and (3) studying the link between cooperative behavior to compliance captured by pill counts and questionnaires.

Conditions

Frontal Lobe Epilepsies

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Patients

Group Type: EXPERIMENTAL

functional magnetic resonance imaging exam

Intervention Type: RADIATION

Controls

Group Type: ACTIVE_COMPARATOR

functional magnetic resonance imaging exam

Intervention Type: RADIATION

Interventions

functional magnetic resonance imaging exam

Intervention Type: RADIATION

Other Intervention Names

fMRI exam

Eligibility Criteria

Inclusion Criteria

• Age between 18 and 50
• Diagnosis of frontal lobe epilepsy
• Written consent to participate
• Right-handed
• Hospital Anxiety and Depression Scale Score under 10
• Obsessive Compulsive Inventory Score under 40
• Sufficient language skills
• Social insurance

• Age between 18 and 50
• Written consent to participate
• Right-handed
• Hospital Anxiety and Depression Scale Score under 10
• Obsessive Compulsive Inventory Score under 40
• Sufficient language skills
• Social insurance

Exclusion Criteria

• Seizures types other than epileptic (psychogenic etc.)
• Mental retardation
• Epilepsies other than FLE
• Other known neurological diseases
• Hospital Anxiety and Depression Scale Score over 10
• Obsessive Compulsive Inventory Score over 40
• Pregnancy
• non-MRI suitable transplants (cardiac pacemaker etc.), claustrophobia, orthopedic diseases that prevent lying in the scanner
• During exclusion period of other studies
• No social insurance

• History of neurological or psychiatric diseases
• Hospital Anxiety and Depression Scale Score over 10
• Obsessive Compulsive Inventory Score over 40
• Medication other than contraceptives
• Pregnancy
• non-MRI suitable transplants (cardiac pacemaker etc.), claustrophobia, orthopedic diseases that prevent lying in the scanner
• Major perceptive impairments
• During exclusion period of other studies
• No social insurance

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hospices Civils de Lyon

Lyon, , France

Countries

France

References

Javor A, Ciumas C, Ibarrola D, Ryvlin P, Rheims S. Social cognition, behaviour and therapy adherence in frontal lobe epilepsy: a study combining neuroeconomic and neuropsychological methods. R Soc Open Sci. 2019 Aug 28;6(8):180850. doi: 10.1098/rsos.180850. eCollection 2019 Aug.

Reference Type: BACKGROUND

PMID: 31598216 (View on PubMed)

Other Identifiers

69HCL14-0269

Identifier Type: -

Identifier Source: org_study_id