In Vitro Models of Liver and Pancreatic Cancer

NCT ID: NCT02436564

Last Updated: 2016-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-07-31

Brief Summary

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The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue. The secondary objective is to study the genetic and cellular biology of cancer of the liver, biliary tract and the pancreas. As well the investigators hope to compare molecular and cellular biology of cancer cells with normal cells as well as potentially test the efficacy of current and future anti-cancer therapies.

Samples will be collected from tissue that has been resected as part of the treatment for a patient diagnosed with liver, bile duct or pancreas cancer.

Detailed Description

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Conditions

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Cholangiocarcinoma Hepatocellular Carcinoma Pancreatic Neoplasm

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Organoid in vitro culture

Generation of 'organoids' using in vitro culture techniques, genomic DNA and RNA sequencing, application of genome editing technology, investigation of anti-tumour drugs, investigation of biological and functional properties of tumour cells, transplantation of organoid lines into animal models.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* All adult patients undergoing surgical resections for liver, biliary or pancreas cancers that are able to give informed consent.

Exclusion Criteria

* Patients aged \<18 or those who are unable to give informed consent.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Gurdon Institute

UNKNOWN

Sponsor Role collaborator

Ann McLaren Laboratory of Regenerative Medicine

UNKNOWN

Sponsor Role collaborator

Cambridge University Hospitals NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Dr. Kourosh Saeb-Parsy

University Lecturer and Consulatan Transplant Surgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kourosh Saeb-Parsy, PhD, FRCS

Role: PRINCIPAL_INVESTIGATOR

Cambridge Univeristy Hospitals

Locations

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Addenbrooke's Hospital

Cambridge, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Kourosh Saeb-Parsy, PhD, FRCS

Role: CONTACT

(+44 1223 7) 68456

Nikitas Georgakopoulos, BSc

Role: CONTACT

07554003700

Facility Contacts

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Andrew Bradley, PhD, FRCS

Role: primary

(3)36976 (7)62001

Other Identifiers

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A093484

Identifier Type: -

Identifier Source: org_study_id

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