The Effect of Different Lining Strategies on Amalgam Restorations

NCT ID: NCT02435459

Last Updated: 2015-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

640 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2017-12-31

Brief Summary

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The aim of this research is to compare the clinical outcome of amalgam restorations placed in conjunction with three different lining protocols, each of which represents a different therapeutic concept.

Detailed Description

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Patients attending one of eight, United Kingdom general dental practitioners for a new restoration in a posterior tooth will be recruited and informed consent obtained. Each dentist will place 20 amalgam restorations either unlined (control), or lined with calcium hydroxide cement, rmgi cement, or sealed with a resin bonding agent (total - 640).

Pre-operative radiographs and pulp testing will be performed and measurement of cavity size to assess the remaining dental thickness. The pulp status and symptoms will be recorded at 6, 12, and 24 months. Post-operative sensitivity will be recorded by the patient at 1, 3, 7, 14 and 28 days using a visual analogue scale and diary. The dentists will be trained and calibrated to use United States Public Health Service criteria and the condition of the restoration will be assessed at 12 and 24 months.

For each lining option, one product and one admixed amalgam will be provided for use by all the dentists. Training and instruction will be given on the application of the liners and on amalgam condensation to increase standardisation.

The collected data will be assessed to identify any association between the outcome variables and the pre-treatment tooth condition or lining material used using logistic regression (α=0.05).

Conditions

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Post-operative Pain Dental Caries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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No lining

No lining material placed under amalgam dental restoration

Group Type PLACEBO_COMPARATOR

No lining

Intervention Type PROCEDURE

No lining material placed under amalgam dental restorations

Calcium hydroxide cement

Placement of calcium hydroxide cement under amalgam dental restorations

Group Type ACTIVE_COMPARATOR

Calcium Hydroxide cement

Intervention Type PROCEDURE

placement of lining material under amalgam dental restorations

Bonding agent

Placement of Resin bonding agent under amalgam dental restorations

Group Type ACTIVE_COMPARATOR

Resin Bonding Agent

Intervention Type PROCEDURE

placement of lining material under amalgam dental restorations

RMGI cement

Placement of rmgi lining under amalgam dental restorations

Group Type ACTIVE_COMPARATOR

RMGI cement

Intervention Type PROCEDURE

placement of lining material under amalgam dental restorations

Interventions

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No lining

No lining material placed under amalgam dental restorations

Intervention Type PROCEDURE

Calcium Hydroxide cement

placement of lining material under amalgam dental restorations

Intervention Type PROCEDURE

RMGI cement

placement of lining material under amalgam dental restorations

Intervention Type PROCEDURE

Resin Bonding Agent

placement of lining material under amalgam dental restorations

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Healthy adults over 18 years
* Presence of one or more carious cavities extending beyond the outer 1/3 of the dentine
* Able to give valid consent to participate in study
* Willing to receive an amalgam restoration in a target tooth
* Teeth free from pain
* Teeth with vital pulps

Exclusion Criteria

* Replacement restorations
* Psychiatric conditions or medication which may affect pain perception.
* Cavities limited to the outer ⅓ of dentine.
* Teeth with existing symptoms or sensitivity
* Patients under 18 years
* Non-vital teeth
* Allergy or idiosyncratic reaction to the study materials
* Inability to return for review
* Fractured or cracked teeth
* Pregnancy or breast-feeding
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shirley Glasstone Hughes Trust Fund

UNKNOWN

Sponsor Role collaborator

University of Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Dominic Stewardson

Senior Lecturer in Restorative Dentistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dominic A Stewardson, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Birmingham, School of Dentistry

Locations

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University of Birmingham, School of Dentistry

Birmingham, West Midlands, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Dominic A Stewardson, PhD

Role: CONTACT

0121 4665489

Kirsty B Hill, PhD

Role: CONTACT

0121 4665488

Facility Contacts

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Dominic A Stewardson, PhD

Role: primary

0121 4665489

Kirsty B Hill, PhD

Role: backup

0121 4665488

Other Identifiers

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RG_12-054

Identifier Type: -

Identifier Source: org_study_id

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