The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity

NCT ID: NCT02434783

Last Updated: 2016-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

16 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-04-30

Brief Summary

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Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles.

This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.

Detailed Description

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Conditions

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Intermittent Claudication

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1st level of arterial insufficiency

asymptomatic PAD patients

No interventions assigned to this group

2nd level of arterial insufficiency

Intermittent claudication patients

No interventions assigned to this group

3rd level of arterial insufficiency

Critical limb ischemia patients

No interventions assigned to this group

No arterial insufficiency

Healthy individuals (control)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Asymptotic peripheral arterial disease (Ankle-brachial index \< 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index \< 0.4)

Exclusion Criteria

* Diagnosed with intermittent claudication secondary to vascular insufficiency
* Warfarin or heparin usage
* Underwent a vascular intervention in the last 6 months
* Active cancer, renal- or liver disease
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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St. Olavs Hospital

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Øyvind Rognmo

Role: STUDY_DIRECTOR

Norwegian University of Science and Technology

Locations

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Department of Circulation and Medical Imaging

Trondheim, , Norway

Site Status

Countries

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Norway

Other Identifiers

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2015/204

Identifier Type: -

Identifier Source: org_study_id

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