Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula
NCT ID: NCT02429817
Last Updated: 2016-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
6 participants
INTERVENTIONAL
2015-04-30
2016-12-31
Brief Summary
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On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.
Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
DOUBLE
Study Groups
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Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Technetium-99m - Diethylenetriaminepentaacetic acid
99mTc-DTPA solution placed on the nebulizer reservoir
Aeroneb Solo
Single photon emission computed tomography
Imaging technique to investigate lung aerosol distribution
Spirometry
FEV1, FVC assessment
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Technetium-99m - Diethylenetriaminepentaacetic acid
99mTc-DTPA solution placed on the nebulizer reservoir
Jet Nebulizer
Single photon emission computed tomography
Imaging technique to investigate lung aerosol distribution
Spirometry
FEV1, FVC assessment
Interventions
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Technetium-99m - Diethylenetriaminepentaacetic acid
99mTc-DTPA solution placed on the nebulizer reservoir
Aeroneb Solo
Jet Nebulizer
Single photon emission computed tomography
Imaging technique to investigate lung aerosol distribution
Spirometry
FEV1, FVC assessment
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
65 Years
MALE
Yes
Sponsors
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Responsible Party
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Locations
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Cliniques Universitaires Saint-Luc
Brussels, , Belgium
Countries
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Other Identifiers
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Aerospect-02
Identifier Type: -
Identifier Source: org_study_id