Comparison of Lung Deposition With the Aeroneb Solo Adapter and a Standard Jet Nebulizer by SPECT-CT
NCT ID: NCT02298101
Last Updated: 2015-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
6 participants
INTERVENTIONAL
2014-09-30
Brief Summary
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It's known that using a spacer during nebulization improves aerosol delivery. We hypothetized that lung deposition could be highly increased with the Aeroneb Solo Adapter in comparison to a standard jet nebulizer.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Aeroneb Solo Adapter
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo Adapter
Technetium-99m - Diethylenetriaminepentaacetic acid
Solution placed on the nebulizer reservoir
Aeroneb Solo Adapter
Nebulizer
Planar scintigraphy
Imaging technique to investigate whole lung deposition
Single photon emission computed tomography
Imaging technique to investigate regional pulmonary deposition
Spirometry
FEV1, FVC assessment
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via a standard jet nebulizer, the Opti-Mist Plus Nebulizer
Technetium-99m - Diethylenetriaminepentaacetic acid
Solution placed on the nebulizer reservoir
Opti-Mist Plus Nebulizer
Standard jet nebulizer
Planar scintigraphy
Imaging technique to investigate whole lung deposition
Single photon emission computed tomography
Imaging technique to investigate regional pulmonary deposition
Spirometry
FEV1, FVC assessment
Interventions
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Technetium-99m - Diethylenetriaminepentaacetic acid
Solution placed on the nebulizer reservoir
Aeroneb Solo Adapter
Nebulizer
Opti-Mist Plus Nebulizer
Standard jet nebulizer
Planar scintigraphy
Imaging technique to investigate whole lung deposition
Single photon emission computed tomography
Imaging technique to investigate regional pulmonary deposition
Spirometry
FEV1, FVC assessment
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
90 Years
MALE
Yes
Sponsors
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Responsible Party
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Locations
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Cliniques Universitaires Saint-Luc
Brussels, , Belgium
Countries
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References
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Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F, Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharm Res. 2017 Feb;34(2):290-300. doi: 10.1007/s11095-016-2061-7. Epub 2016 Nov 7.
Other Identifiers
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AeroSpect-01
Identifier Type: -
Identifier Source: org_study_id