Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

NCT ID: NCT02394743

Last Updated: 2016-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

360 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-03-31

Study Completion Date

2016-09-30

Brief Summary

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Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Renal insufficiency is close correlation with atherosclerosis and cardiovascular mortality.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between eGFR and vascular inflammation detected by 18F FDG-PET.

Detailed Description

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Conditions

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Atherosclerosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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eGFR > 90

group whose eGFR is more than 90

18FDG-PET

Intervention Type RADIATION

60 < eGFR <90

group whose eGFR is between 60 and 90

18FDG-PET

Intervention Type RADIATION

eGFR < 60

group whose eGFR is less than 60

18FDG-PET

Intervention Type RADIATION

Interventions

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18FDG-PET

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

1. absence of prior cancer diagnosis or remission from cancer at the time of PET imaging and throughout the follow-up period;
2. \>=30 years of age;
3. no prior history of cardiovascular disease ; and
4. absence of acute or chronic inflammatory or autoimmune disease (based on documented medical history) or use of chronic anti-inflammatory therapy.

Exclusion Criteria

1. age \<35 years
2. presence of chronic inflammatory disease
3. use of anti-inflammatory medications
4. presence of active malignant cancer (defined as any radiological or pathological evidence of malignant cancer disease or undergoing chemotherapy or radiation therapy within 1 year before initial PET/CT and throughout the inter-scan duration).
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Korea University

OTHER

Sponsor Role lead

Responsible Party

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Kyung Mook Choi

Medical professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Internal Medicine, Korea University College of Medicine

Seoul, VD, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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PET_eGRF

Identifier Type: -

Identifier Source: org_study_id

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