Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients

NCT ID: NCT02387541

Last Updated: 2016-05-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-03-31
• Study Completion Date: 2014-01-31

Brief Summary

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

Detailed Description

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

Conditions

Perioperative Complications

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• aged ≥65 years;
• ASA I or Ⅱ;
• total knee replacement

Exclusion Criteria

• Mini Mental State Examination [MMSE] score too low.
• Parkinson or other neurological disease causing functional impairment.
• Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

General Hospital of Ningxia Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

NZ10145

Identifier Type: -

Identifier Source: org_study_id