Postprandial Differences After Herring and Beef

NCT ID: NCT02381613

Last Updated: 2015-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2015-03-31

Brief Summary

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While observational studies often find that diets rich in fish reduce the risk of disease, and that diets including a high intake of red meat are associated with increased risk of cardiovascular disease and cancer, the difference in health effects between red meat and fish are rarely researched in intervention studies.

The investigators hypothesise that the post-prandial plasma response of lipids and markers of cardiovascular disease risk will be more favourable after intake of herring compared to beef.

In addition, while pickling herring in a brine/sugar solution is a common form of preparation, little is known if there is a difference in potential health effects based on the preparation of herring. The investigators will compare baked and pickled herring to understand if preparation is potentially an important factor to be considered when looking at intake of fish and health.

Detailed Description

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Conditions

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Cardiovascular Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Baked beef

A meal based on baked beef

Group Type ACTIVE_COMPARATOR

Baked beef

Intervention Type OTHER

A meal based on baked beef

Baked herring

A meal based on baked herring

Group Type EXPERIMENTAL

Baked herring

Intervention Type OTHER

A meal based on baked herring

Pickled herring

A meal based on pickled herring

Group Type EXPERIMENTAL

Pickled herring

Intervention Type OTHER

A meal based on pickled herring

Interventions

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Baked beef

A meal based on baked beef

Intervention Type OTHER

Baked herring

A meal based on baked herring

Intervention Type OTHER

Pickled herring

A meal based on pickled herring

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* 35-67 years
* BMI \>30 kg/m2
* Normally eats lunch and dinner

Exclusion Criteria

* Smoke or oral tobacco use
* Use of prescription or recreational drugs likely to interfere with primary outcome
* Change in body weight in the month prior to the study
* Abnormal blood biomarker values (assessed by a clinician)
Minimum Eligible Age

35 Years

Maximum Eligible Age

67 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Oy Foodfiles Ltd

OTHER

Sponsor Role collaborator

Chalmers University of Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Ross AB, Svelander C, Undeland I, Pinto R, Sandberg AS. Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, beta-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. J Nutr. 2015 Nov;145(11):2456-63. doi: 10.3945/jn.115.214262. Epub 2015 Sep 23.

Reference Type DERIVED
PMID: 26400963 (View on PubMed)

Other Identifiers

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CSP U-12-001

Identifier Type: -

Identifier Source: org_study_id

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